PMID: 15369423Sep 17, 2004Paper

Persistence with lipid-lowering therapy: influence of the type of lipid-lowering agent and drug benefit plan option in elderly patients

Journal of Managed Care Pharmacy : JMCP
Susan M AbughoshJerry H Gurwitz

Abstract

To determine the effects of lipid-lowering agent (LLA) class and drug plan design option on persistence with LLAs among elderly patients enrolled in a managed care plan. A retrospective cohort study was conducted among 310 older adult members enrolled in a health maintenance organization operating in New England who were dispensed an LLA between July 1, 1994, and June 30, 1996. Survival analysis was used to examine differences in discontinuation of LLAs between different classes of LLAs and drug benefit plans as well as patient sex, age, prior hospitalization for coronary heart disease (CHD), hypertension, diabetes mellitus, and the number of other medications. The overall LLA discontinuation rate increased with time from 18% (95% confidence interval [CI], 13.8%-22.4%) at 6 months to 46% (95% CI, 39.7%- 52.5%) at 12 months and 66% (95% CI, 59.2%-73.0%) at 18 months. The likelihood of discontinuation increased from 54% (95% CI, 44.8%-63.6%) at 12 months to 77% (95% CI, 67.5%-85.5%) at 18 months in nonstatin users and from 39% (95% CI, 30.4%-47.6%) at 12 months to 57 % (95% CI, 47.3%-66.9%) at 18 months in statin users (P = 0.001). Among patients prescribed a statin at initial prescription (n = 182), the 12-month discontinuation ...Continue Reading

Citations

Apr 28, 2017·Journal of Managed Care & Specialty Pharmacy·Susan AbughoshMarc Fleming
May 9, 2009·Medical Care Research and Review : MCRR·Adam Atherly, Paul H Rubin
Jun 23, 2007·Health Economics·Patrick ThiebaudMichael B Nichol
Nov 30, 2005·Pharmacoepidemiology and Drug Safety·Anthony GichangiWerner Vach
Feb 13, 2007·The American Journal of Cardiology·Sachin J Kamal-BahlChuck Wentworth
Jan 14, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Michael B NicholMohamed Hussein
Feb 27, 2009·BMC Health Services Research·Anke-Peggy HoltorfGary Oderda
Jul 28, 2009·Pharmacoepidemiology and Drug Safety·Joshua DevineThomas Bacon
Oct 5, 2010·Journal of Hepatology·Watcharasak ChotiyaputtaAnna S F Lok

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