Persistent Activation of the Innate Immune Response in Adult Drosophila Following Radiation Exposure During Larval Development

G3 : Genes - Genomes - Genetics
Lisa J SudmeierBarry Ganetzky

Abstract

Cranial radiation therapy (CRT) is an effective treatment for pediatric central nervous system malignancies, but survivors often suffer from neurological and neurocognitive side effects that occur many years after radiation exposure. Although the biological mechanisms underlying these deleterious side effects are incompletely understood, radiation exposure triggers an acute inflammatory response that may evolve into chronic inflammation, offering one avenue of investigation. Recently, we developed a Drosophila model of the neurotoxic side effects of radiation exposure. Here we use this model to investigate the role of the innate immune system in response to radiation exposure. We show that the innate immune response and NF-ĸB target gene expression is activated in the adult Drosophila brain following radiation exposure during larval development, and that this response is sustained in adult flies weeks after radiation exposure. We also present preliminary data suggesting that innate immunity is radioprotective during Drosophila development. Together our data suggest that activation of the innate immune response may be beneficial initially for survival following radiation exposure but result in long-term deleterious consequences,...Continue Reading

References

Oct 15, 1995·International Journal of Radiation Oncology, Biology, Physics·J H HongW H McBride
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·P RubinJ N Finkelstein
Oct 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C S ChiangH R Withers
Jan 1, 1996·Annual Review of Cell and Developmental Biology·M P Belvin, K V Anderson
Apr 17, 2001·International Journal of Radiation Biology·K NeriishiR R Delongchamp
Dec 18, 2001·Nature Immunology·Servane Tauszig-DelamasureJean-Luc Imler
May 17, 2002·The New England Journal of Medicine·Fred A Mettler, George L Voelz
Jun 25, 2003·Toxicology·Joseph F Weiss, Michael R Landauer
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger J PackerLeslie L Robison
May 27, 2004·Radiation Research·Michiko YamadaGen Suzuki
Jun 18, 2004·Immunological Reviews·Philippe BuletLaure Menin
Jan 11, 2005·The American Journal of Medicine·Tomonori HayashiKei Nakachi
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raymond K MulhernAmar Gajjar
Jan 5, 2007·Annual Review of Immunology·Bruno Lemaitre, Jules Hoffmann
Jun 19, 2009·Journal of the National Cancer Institute·Gregory T ArmstrongRoger J Packer
Dec 29, 2010·Cell Research·Shigeki Miyamoto
Jan 7, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna ValanneMika Rämet
Jun 8, 2011·Journal of Pediatric Hematology/oncology·Kim EdelsteinBrenda J Spiegler
Feb 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andrew J PetersenDavid A Wassarman
Aug 9, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tomonori HayashiKei Nakachi
Oct 30, 2012·Journal of Radiation Research·Zhiqiang HuZhongbin Chen
Apr 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yang CaoBarry Ganetzky
Jul 3, 2013·Nature Reviews. Drug Discovery·Everett J ModingDavid G Kirsch
Aug 21, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ilse SchuitemaLeo M J de Sonneville
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rebeccah J KatzenbergerDavid A Wassarman
Apr 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henna MyllymäkiMika Rämet
Jun 21, 2015·Disease Models & Mechanisms·Lisa J SudmeierBarry Ganetzky

❮ Previous
Next ❯

Citations

Dec 14, 2018·International Journal of Molecular Sciences·Shu Hui Lye, Stanislava Chtarbanova
May 21, 2019·Frontiers in Neuroscience·Ekta J ShahDouglas M Ruden
Feb 5, 2021·CNS Neuroscience & Therapeutics·Nurul Atiqah ZulazmiMohd Farooq Shaikh
Dec 14, 2019·Current Opinion in Immunology·Mark Austin Hanson, Bruno Lemaitre
May 29, 2018·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Weiwei MaYi Zhong

❮ Previous
Next ❯

Methods Mentioned

BETA
irradiating
PCR
confocal microscopy

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.