Persistent alterations in the T-cell repertoires of HIV-1-infected and at-risk uninfected men

AIDS
M Scott KillianBeth D Jamieson

Abstract

We examined the association between immunogenic exposure and T-cell receptor (TCR) diversity to more clearly assess the impact of HIV-1 infection on the T-cell repertoire. : To estimate the extent of T-cell clonality attributable to HIV-1 infection, we evaluated T-cell repertoires in low-risk and at-risk seronegative men and HIV-1 seropositive men by assessment of T-cell receptor beta-chain (TCR beta) complimentary determining region 3 (CDR3) lengths. The frequency of T-cell clonality in both HIV-1 infected and at-risk uninfected men was elevated in comparison to low-risk uninfected men. Among low-risk and at-risk seronegative, and HIV-1 seropositive men, clonal expansions were present in 3, 8, and 10% of CD4+ CDR3 lengths, and 18, 22, and 28% of CD8+ CDR3 lengths respectively. In addition, the longitudinal conservation of clonal expansions was observed in at-risk seronegative men. Based on comparisons to at-risk seronegative men, we estimate that at-risk seropositive men with chronic HIV-1 infection exhibit a 27% increase in the number of expanded CD8+ CDR3 lengths. These findings provide an approximation of the magnitude of the T-cell response in individuals undergoing chronic HIV-1 infection and demonstrate a significant ass...Continue Reading

References

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Citations

Feb 25, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marta Rodríguez-GarcíaTeresa Gallart
Nov 26, 2009·AIDS·Daniel Malamud, Sharon M Wahl
May 3, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Patrick H K Ngai, T B Ng
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