Persistent alterations in the T-cell repertoires of HIV-1-infected and at-risk uninfected men

M Scott KillianBeth D Jamieson


We examined the association between immunogenic exposure and T-cell receptor (TCR) diversity to more clearly assess the impact of HIV-1 infection on the T-cell repertoire. : To estimate the extent of T-cell clonality attributable to HIV-1 infection, we evaluated T-cell repertoires in low-risk and at-risk seronegative men and HIV-1 seropositive men by assessment of T-cell receptor beta-chain (TCR beta) complimentary determining region 3 (CDR3) lengths. The frequency of T-cell clonality in both HIV-1 infected and at-risk uninfected men was elevated in comparison to low-risk uninfected men. Among low-risk and at-risk seronegative, and HIV-1 seropositive men, clonal expansions were present in 3, 8, and 10% of CD4+ CDR3 lengths, and 18, 22, and 28% of CD8+ CDR3 lengths respectively. In addition, the longitudinal conservation of clonal expansions was observed in at-risk seronegative men. Based on comparisons to at-risk seronegative men, we estimate that at-risk seropositive men with chronic HIV-1 infection exhibit a 27% increase in the number of expanded CD8+ CDR3 lengths. These findings provide an approximation of the magnitude of the T-cell response in individuals undergoing chronic HIV-1 infection and demonstrate a significant ass...Continue Reading


Jun 1, 1989·The Journal of Experimental Medicine·Beth D Jamieson, R Ahmed
Aug 4, 1988·Nature·M M Davis, P J Bjorkman
Jun 1, 1984·The British Journal of Venereal Diseases·A Mindel, S Sutherland
Jun 23, 1994·Nature·L L LauR Ahmed
Jul 7, 1995·Annals of the New York Academy of Sciences·P K GregersenJ Monteiro
Jan 1, 1993·The Journal of Infectious Diseases·D H OsmondA Reingold
Mar 20, 1993·Annals of the New York Academy of Sciences·Janis V Giorgi
Jan 1, 1997·AIDS·J L Gerberding
May 23, 1998·Annual Review of Immunology·R W DuttonS L Swain
Jan 5, 1999·Clinical and Diagnostic Laboratory Immunology·C A KleebergerJanis V Giorgi
Jun 15, 1999·Immunity·Beth D JamiesonJ A Zack
Nov 13, 1999·Science·K Murali-KrishnaR Ahmed
Dec 2, 1999·Nature·A W Goldrath, M J Bevan
Jan 10, 2001·The Journal of Experimental Medicine·P J GoulderC Brander
Apr 24, 2001·The Tohoku Journal of Experimental Medicine·R Dehari
Mar 28, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Janis V GiorgiMulticenter AIDS Cohort Study
May 3, 2002·Nature·Daniel C DouekRichard A Koup
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·M Scott KillianBeth D Jamieson
Oct 25, 2002·AIDS Research and Human Retroviruses·Otto O YangJanis V Giorgi


Feb 25, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marta Rodríguez-GarcíaTeresa Gallart
Nov 26, 2009·AIDS·Daniel Malamud, Sharon M Wahl
May 3, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Patrick H K Ngai, T B Ng
Jun 7, 2006·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Marilia Cascalho, Jeffrey L Platt
Mar 3, 2010·PLoS Pathogens·Benoît VingertANRS EP36 HIV Controllers Study Group
Jan 6, 2016·AIDS·Christian R Aguilera-SandovalPaul Krogstad
May 10, 2008·Science·John P MooreSunil K Ahuja
Sep 1, 2005·Journal of Immunological Methods·M Scott KillianJay A Levy
Oct 12, 2011·Journal of Immunological Methods·Sarfraz A MemonFrances T Hakim
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brenda M OgleJeffrey L Platt
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan D KilpatrickBeth D Jamieson
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mouhammed AbuAttiehMarilia Cascalho
Oct 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arumugam BalamuruganOtto O Yang

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