Persistent and recurrent hyperparathyroidism

Current Treatment Options in Oncology
Nadine R CaronO H Clark

Abstract

More than 95% of patients with primary hyperparathyroidism (HPT) will be cured at initial operation by an experienced surgeon. Despite this success rate, persistent and recurrent HPT remain challenging clinical entities. The most cost effective and safest treatment for persistent and recurrent HPT is avoidance by successful first operation. The contributors to treatment failure can be categorized into factors related to the initial surgical procedure, anatomic variability, and the biology of disease. An understanding of the factors that commonly contribute to treatment failure can help prevent persistent and recurrent disease and plays an integral role in planning subsequent surgical approaches. Once a biochemical diagnosis of persistent or recurrent HPT is confirmed, a thorough evaluation of previous operative, pathology, and radiology reports is essential. Localization procedures supplement this information and help direct the reoperative approach. When complementary noninvasive studies, such as ultrasound, sestamibi, and magnetic resonance imaging are negative, equivocal, or discordant, invasive tests (eg, selective venous sampling for parathyroid hormone levels) are warranted. Intraoperative ultrasound and gamma-probe local...Continue Reading

References

Nov 1, 1990·World Journal of Surgery·G HedbäckA Oden
Dec 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J A PallottaH Eisenberg
Aug 1, 1996·Archives of Surgery·W ShenO H Clark
Mar 1, 1997·European Journal of Endocrinology·F N BennedbaekL Hegedüs
Mar 11, 1998·The Australian and New Zealand Journal of Surgery·C WadströmL Delbridge
Jun 6, 1998·European Journal of Clinical Investigation·G Hedbäck, A Odén
Jun 26, 1998·Langenbeck's Archives of Surgery·C MarietteC Proye
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·M Abdelhadi, J Nordenström
Jan 20, 1999·European Journal of Clinical Investigation·G Hedbäck, A Odén
Oct 30, 1999·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·J MundschenkH Lehnert
Oct 18, 2000·Endocrinology and Metabolism Clinics of North America·M S Eigelberger, O H Clark
Oct 18, 2000·Endocrinology and Metabolism Clinics of North America·G J Strewler
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R Zanchetta, C E Bogado
Oct 20, 2001·Notes and Records of the Royal Society of London·D C Watt
Mar 27, 2002·Langenbeck's Archives of Surgery·Johnathan G H HubbardJean-François Henry
Apr 20, 2002·World Journal of Surgery·Daishu MiuraOrlo H Clark
Jun 12, 2002·Current Treatment Options in Oncology·E Kebebew
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·John P BilezikianSamuel A Wells
Dec 17, 2002·Current Opinion in Pharmacology·Adi Cohen, Shonni J Silverberg
May 20, 2003·Kidney International. Supplement·Pablo Ureña, João M Frazão
Jun 20, 2003·Current Opinion in Nephrology and Hypertension·L Darryl Quarles
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Orlo H Clark
Aug 20, 2003·Archives of Otolaryngology--head & Neck Surgery·Eric J LentschJeffrey M Bumpous
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·UNKNOWN Consensus Development Task Force on Diagnosis and Management of Asymptomatic Primary Hyperparathyroidism
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Dolores M ShobackMunro Peacock

❮ Previous
Next ❯

Citations

Aug 24, 2006·Annals of Surgery·Robert Udelsman, Patricia Irvin Donovan
Sep 18, 2009·Annals of Surgical Oncology·Ashley K CayoHerbert Chen
Dec 24, 2010·AJR. American Journal of Roentgenology·Michael D BelandJack M Monchik
Mar 13, 2008·World Journal of Surgery·Ola HessmanGöran Akerström
May 27, 2014·The Surgical Clinics of North America·Dina Elaraj, Cord Sturgeon
Apr 18, 2013·American Journal of Surgery·Debra D DavisSam M Wiseman
Nov 4, 2010·Current Problems in Surgery·Joel T AdlerHerbert Chen
Dec 2, 2008·Otolaryngologic Clinics of North America·David Goldenberg
May 13, 2008·Journal of the American College of Surgeons·Melinda M MortensonNancy D Perrier
Oct 31, 2014·Annals of Surgical Oncology·Heather WachtelDouglas L Fraker
Dec 3, 2014·Journal of Vascular and Interventional Radiology : JVIR·Michael GinsburgEdwin L Kaplan
Mar 22, 2007·Acta Cirúrgica Brasileira·Elaine Maria Santos GomesManuel Domingos da Cruz Gonçalves
Sep 23, 2008·Clinical Nuclear Medicine·Ashley Cayo, Herbert Chen
Jun 27, 2008·Annals of Surgery·Frédéric TriponezPieter Evenepoel
Jul 3, 2007·The Oncologist·James W Suliburk, Nancy D Perrier
Feb 14, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Douglas L Fraker
Apr 24, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Serena GrimaldiDésirée Deandreis
Apr 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jacek BajGabriella Garruti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.