PMID: 9525685Apr 3, 1998Paper

Persistent antibody responses but declining cytotoxic T-lymphocyte responses to multiple human immunodeficiency virus type 1 antigens in a long-term nonprogressing individual with a defective p17 proviral sequence and no detectable viral RNA expression

Journal of Virology
J M BinleyJ P Moore

Abstract

Long-term nonprogressor AD-18 has been infected with human immunodeficiency virus type 1 (HIV-1) for at least 16 years. During the past 5 years, he has had undetectable levels of plasma viremia, and HIV-1 cannot be isolated from him. Sequencing of proviral DNA indicates that the only HIV-1 sequences that can be identified in AD-18 have gross defects in the p17-encoding regions of the gag gene (Y. Huang, L. Zhang, and D. D. Ho, Virology 240:36-49, 1998). However, AD-18 has strong, sustained antibody responses to several HIV-1 antigens, including p17. Cytotoxic T-lymphocyte responses to Env and Gag antigens have gradually diminished over the past 4 years, at a time when the titers of antibodies to the same proteins have remained stable. We discuss what these observations might mean for the generation and maintenance of immunological memory.

References

Jan 26, 1995·The New England Journal of Medicine·F KirchhoffR C Desrosiers
Apr 5, 1996·Science·M A Nowak, C R Bangham
Mar 1, 1996·AIDS Research and Human Retroviruses·D R PremkumarH W Kestler
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·P KlenermanM A Nowak
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·S BonhoefferM A Nowak

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Citations

Jun 18, 1999·Reviews in Medical Virology·A M Geretti
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mohan SomasundaranMario Stevenson
Feb 8, 2006·The Pediatric Infectious Disease Journal·Louis AlexanderWarren A Andiman

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