Persistent changes in action potential broadening and the slow afterhyperpolarization in rat CA1 pyramidal cells after febrile seizures

The European Journal of Neuroscience
A KamalGeert M J Ramakers

Abstract

Febrile (fever-induced) seizures (FS) are the most common form of seizures during childhood and have been associated with an increased risk of epilepsy later in life. The relationship of FS to subsequent epilepsy is, however, still controversial. Insights from animal models do indicate that especially complex FS are harmful to the developing brain and contribute to a hyperexcitable state that may persist for life. Here, we determined long-lasting changes in neuronal excitability of rat hippocampal CA1 pyramidal cells after prolonged (complex) FS induced by hyperthermia on postnatal day 10. We show that hyperthermia-induced seizures at postnatal day 10 induce a long-lasting increase in the hyperpolarization-activated current I(h). Furthermore, we show that a reduction in the amount of spike broadening and in the amplitude of the slow afterhyperpolarization following FS are also likely to contribute to the hyperexcitability of the hippocampus long term.

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Citations

Mar 28, 2008·Genes, Brain, and Behavior·K L I van GassenP N E de Graan
Apr 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roland A BenderTallie Z Baram
Jan 18, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ebrahim RajabAmer Kamal
Mar 8, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Katelin P PattersonShlomo Shinnar
Jun 7, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ebrahim RajabAmer Kamal
Dec 8, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Aylin Y ReidQuentin J Pittman
Feb 24, 2009·Brain & Development·Céline M DubéTallie Z Baram
Oct 7, 2008·Progress in Neurobiology·Roland A Bender, Tallie Z Baram
Jul 22, 2010·The European Journal of Neuroscience·Robbert G E NotenboomPierre N E de Graan
Apr 5, 2011·Epilepsy Currents·Tallie Z BaramAmy Brooks-Kayal

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