Feb 9, 2017

Persistent Chemotherapy-Induced Hiccups Successfully Treated with Pregabalin

Gan to kagaku ryoho. Cancer & chemotherapy
Kyoko NakanishiYoshinobu Ohsaki


A 62-year-old male was diagnosed with large cell lung cancer(c-Stage IV)based on pathological examination of an anterior chest tumor. He received chemotherapy with cisplatin, pemetrexed, and bevacizumab. He suffered from persistent hiccups from day 2 of the first course of chemotherapy. He was unsuccessfully treated with chlorpromazine, shakuyakukanzoto, and gabapentin. Therefore, we administered pregabalin to him, and his hiccups subsided immediately. To prevent hiccups, he subsequently took pregabalin along with his chemotherapy regimen, and was able to receive 4 courses of chemotherapy without persistent hiccups. Pregabalin is a possible therapeutic option for treating persistent chemotherapy-induced hiccups.

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Mentioned in this Paper

Adenocarcinoma of Lung (Disorder)
BMS 247616
DRUG Screen Quantitative Gabapentin
Antineoplastic Chemotherapy Protocols
Administration of Antineoplastic Agent

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