Persistent coding of outcome-predictive cue features in the rat nucleus accumbens

ELife
Jimmie M GmazMatthijs Aa van der Meer

Abstract

The nucleus accumbens (NAc) is important for learning from feedback, and for biasing and invigorating behaviour in response to cues that predict motivationally relevant outcomes. NAc encodes outcome-related cue features such as the magnitude and identity of reward. However, little is known about how features of cues themselves are encoded. We designed a decision making task where rats learned multiple sets of outcome-predictive cues, and recorded single-unit activity in the NAc during performance. We found that coding of cue identity and location occurred alongside coding of expected outcome. Furthermore, this coding persisted both during a delay period, after the rat made a decision and was waiting for an outcome, and after the outcome was revealed. Encoding of cue features in the NAc may enable contextual modulation of on-going behaviour, and provide an eligibility trace of outcome-predictive stimuli for updating stimulus-outcome associations to inform future behaviour.

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Citations

Jun 13, 2019·Nature Communications·G Elliott Wimmer, Christian Büchel
Oct 23, 2019·Frontiers in Behavioral Neuroscience·Kelsey M MooreRobert L Meisel

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