Persistent conditioned place preference to cocaine and withdrawal hypo-locomotion to mephedrone in the flatworm planaria

Neuroscience Letters
Claire V HutchinsonColin Davidson

Abstract

The purpose of the present study was to determine the effects of exposure to cocaine and mephedrone on conditioned place preference (CPP) and locomotion in the flatworm planaria. Planaria were treated with either cocaine or mephedrone at 1 or 10 μM. Planaria were exposed to 15 min of drug in their non-preferred place (either a rough- or smooth-floored petri dish) on alternate days, and were exposed to normal water in their preferred place on the following day. There were 5 days of conditioning to drug. Planaria were then tested for CPP on day 2, 6 and 13 after withdrawal. We found that animals exhibited CPP to cocaine at both 1 and 10 μM, but not to mephedrone. When examining locomotor activity we found that neither cocaine nor mephedrone treatment showed any evidence of evoking increased motility or locomotor sensitisation. Hypo-motility was seen on the first day of conditioning at concentrations of 10 μM for both cocaine and mephedrone, but had disappeared by the last day of conditioning. Examining chronic withdrawal, only 10 μM mephedrone had a significant effect on motility, decreasing locomotion on day 2 of withdrawal. Taken together we have shown that cocaine evoked CPP in planaria. We have also shown withdrawal depressin...Continue Reading

References

Feb 1, 1986·Archives of General Psychiatry·F H Gawin, H D Kleber
Sep 1, 1996·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·G PalladiniV Margotta
Aug 16, 2000·Neuroreport·T Kusayama, S Watanabe
Aug 23, 2001·Brain Research. Brain Research Reviews·C DavidsonE H Ellinwood
Feb 1, 2005·Brain Research·Robert B Raffa, Prarthna Desai
Mar 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·B Jill VentonR Mark Wightman
Feb 26, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Francesca R ButtarelliFrancesco E Pontieri
Feb 28, 2009·The International Journal of Developmental Biology·Emili SalóGustavo Rodríguez-Esteban
Aug 26, 2010·Addiction·Adam R WinstockFabrizio Schifano
Aug 19, 2011·Genome Biology·Thomas SandmannKerstin Bartscherer
May 6, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jolanta Opacka-JuffryColin Davidson

❮ Previous
Next ❯

Citations

Feb 12, 2020·British Journal of Clinical Pharmacology·Raquel Santos-ToscanoColin Davidson
Nov 28, 2020·Pharmacology, Biochemistry, and Behavior·Fatih SalGonzalo P Urcelay
Nov 3, 2020·Frontiers in Behavioral Neuroscience·Greer McKendrick, Nicholas M Graziane
Mar 28, 2021·The Science of the Total Environment·Adam Bownik, Donald Wlodkowic
Jun 20, 2021·Physiology & Behavior·Sarah UddinScott M Rawls
May 6, 2019·Neuroscience Letters·Kara Adams, Tom Byrne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.