Persistent dysfunctional frontal lobe activation in former smokers.

Psychopharmacology
Andres NeuhausJ Gallinat

Abstract

Chronic smoking and nicotine exposure are accompanied by impaired cognitive task performance, modulated cerebral activity in brain imaging studies, and neuritic damage in experimental animals. The profile of the described dysfunctions matches frontal lobe circuits which also play a role in reward processing and reinforcement behavior. However, it is largely unknown if cerebral dysfunctions are reversible or persist during long term abstinence. Cortical activation during auditory target processing (oddball task, P300 component) was recorded with 32-channel EEG in 247 healthy subjects consisting of 84 smokers, 53 former smokers (mean time of abstinence 11.9 years), and 110 never smokers. Both current smokers and former smokers exhibited significantly diminished P300 amplitudes (Cz, Pz) relative to never smokers. Neuroelectric source analysis (low resolution brain electromagnetic tomography) revealed a hypoactivation of the anterior cingulate, orbitofrontal, and prefrontal cortex in smokers compared to never smokers. A similar profile of hypoactivation was observed in former smokers. For the first time, evidence is provided that dysfunctional activation of frontal lobe networks in smokers is also present in long term abstainers.

References

Jun 1, 1989·Drug and Alcohol Dependence·F R SnyderJ E Henningfield
Apr 1, 1995·Electroencephalography and Clinical Neurophysiology·P BaudenaJ M Clarke
Oct 1, 1994·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·R D Pascual-MarquiD Lehmann
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A P HolmesI Ford
Dec 6, 1997·Nature·V I PidoplichkoJ A Dani
May 20, 1998·Nature·M P Epping-JordanA Markou
Aug 12, 1998·The American Journal of Psychiatry·E A SteinA S Bloom
Jun 27, 2000·Psychopharmacology·A P AnokhinJ W Rohrbaugh
Jan 3, 2001·Nature Neuroscience·J O'DohertyC Andrews
Mar 7, 2001·Biological Psychiatry·A H Rezvani, E D Levin
May 10, 2001·Schizophrenia Research·M Martín-LoechesT Palomo
Aug 28, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M ErnstE D London
Sep 8, 2001·Brain Topography·G WintererW M Herrmann
Oct 31, 2001·Psychopharmacology·J GallinatU Hegerl
May 16, 2002·Neurotoxicology and Teratology·Theodore A Slotkin
Sep 18, 2002·Brain Research. Developmental Brain Research·Craig J Slawecki, Cindy L Ehlers
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Nov 1, 2002·Neuron·Natalia S LawrenceElliot A Stein
Dec 10, 2002·Archives of General Psychiatry·Arthur L BrodyMurray E Jarvik
Dec 17, 2002·NeuroImage·Jürgen GallinatGeorg Winterer
Feb 4, 2003·The American Journal of Psychiatry·Jed E RoseR Edward Coleman
May 22, 2003·Neurotoxicology and Teratology·Wei-Jung A ChenRebecca J Monk
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yael Abreu-VillaçaTheodore A Slotkin
Jul 26, 2003·NeuroImage·Veena KumariTonmoy Sharma
Aug 23, 2003·Science·Jay A GottfriedRaymond J Dolan
Nov 19, 2003·European Journal of Pharmacology·Huibert D MansvelderArjen B Brussaard
Jan 7, 2004·Biological Psychiatry·Arthur L BrodyEdythe D London
Jan 16, 2004·The American Journal of Geriatric Cardiology·Kenneth J Mukamal
Apr 15, 2004·Current Opinion in Neurobiology·Rudolf N Cardinal, Barry J Everitt

❮ Previous
Next ❯

Citations

Oct 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Leon Kenemans, Seppo Kähkönen
Dec 8, 2007·Nature Reviews. Drug Discovery·Daniel C JavittMihály Hajós
Aug 22, 2007·Traffic Injury Prevention·Gabriel E RybCarl Soderstrom
Mar 12, 2011·Addiction Biology·Jürgen BrinkmeyerGeorg Winterer
Nov 22, 2011·Journal of Cognitive Neuroscience·Muhammad A ParvazRita Z Goldstein
Jun 19, 2009·Clinical EEG and Neuroscience·Natalie A CeballosRebecca J Houston
May 23, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dawson Hedges, David P Bennett
Jan 17, 2007·Journal of Clinical Psychopharmacology·Jürgen GallinatFlorian Schubert
Jan 12, 2007·Journal of Cognitive Neuroscience·Jürgen GallinatGeorg Winterer
Dec 22, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Sanaa A M ElgayarHuda S A Thabet
Jan 11, 2016·Journal of Neuroscience Research·Farid MotlaghHussain Habil
Sep 30, 2010·Biological Psychiatry·Simone KühnJürgen Gallinat
Jul 1, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Figen GuneyBilge Cetin Ilhan
Nov 4, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·G LaheraJ Saiz-Ruiz
Jan 28, 2009·Human Brain Mapping·Andres H NeuhausMichael Dettling
Sep 29, 2006·The European Journal of Neuroscience·Jürgen GallinatMario Staedtgen
Oct 5, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Georg WintererDan Rujescu
Aug 19, 2010·The American Journal on Addictions·Lance BauerVictor Hesselbrock
Oct 19, 2006·Brain Research·Jaime Owner A Pineda, Lindsay M Oberman
Mar 13, 2010·Neuroscience and Biobehavioral Reviews·Jodie FeilJohn L Bradshaw

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
John Polich, Christian J Ochoa
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Figen GuneyBilge Cetin Ilhan
The European Journal of Neuroscience
Jürgen GallinatMario Staedtgen
© 2022 Meta ULC. All rights reserved