Persistent elevation of plasma vascular endothelial growth factor levels during the first month after minimally invasive colorectal resection.

Surgical Endoscopy
A BelizonR L Whelan

Abstract

Elevations of plasma vascular endothelial growth factor (VEGF) have been noted early after colorectal resection. The duration of this increase is unknown. Because VEGF is a potent promoter of angiogenesis, which is critical to tumor growth, a sustained increase in blood VEGF levels after surgery may stimulate the growth of residual metastases early after surgery. This preliminary study aimed to determine VEGF levels during the first month after colorectal resection. Patients from three prospective studies that had late postoperative blood samples available comprised the study population. Demographic, perioperative, pathologic, and complication data were collected. Plasma samples were obtained preoperatively for all patients: on postoperative day (POD) 1 for most patients and at varying time points thereafter during the first month after surgery and beyond. Levels of VEGF were determined via enzyme-linked immunoassay (ELISA) and compared using Wilcoxon's matched pairs test. Because the numbers of specimens beyond POD 5 were limited, samples from 7-day time blocks were bundled and averaged to permit statistical analysis. A total of 49 patients with cancer and 30 patients with benign indications, all of whom underwent minimally in...Continue Reading

References

Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jun 1, 1997·Infection and Immunity·T HenslerB Holzmann
Jun 1, 1997·Nature Biotechnology·J Folkman
Aug 26, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·S GradF E Maly
Oct 22, 1998·The British Journal of Surgery·M L Da CostaD Bouchier-Hayes
Dec 9, 1998·Digestive Surgery·W HauptW Hohenberger
Oct 30, 1999·Japanese Journal of Cancer Research : Gann·K SatoT Kato
Sep 27, 2000·Neoplasia : an International Journal for Oncology Research·J L RubensteinM A Shuman
Nov 18, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K WertherH J Nielsen
Mar 5, 2002·British Journal of Cancer·K WertherUNKNOWN Danish RANX05 Colorectal Cancer Study Group
Oct 16, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masataka IkedaTakashi Satomi
Mar 13, 2003·Journal of Pediatric Surgery·Kimberly W McCruddenWilliam Middlesworth
Jun 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jianzhong HuangJessica J Kandel
Oct 1, 2003·Angiogenesis·E T BishopD N Wheatley
Nov 1, 2003·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A J KarayiannakisC Simopoulos
Nov 30, 2004·Journal of Clinical Anesthesia·Christer H Svensén
Jun 21, 2005·The Journal of Laboratory and Clinical Medicine·Krishnamurthy P GudehithluAshok K Singh
Jul 22, 2005·Journal of Biomedical Materials Research. Part a·Yoshihiro ItoTakashi Kitajima
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200

❮ Previous
Next ❯

Citations

Jul 3, 2009·Surgical Endoscopy·Melanie GoldfarbS D Schwaitzberg
Sep 11, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H M C Shantha KumaraR L Whelan
Apr 2, 2015·The Indian Journal of Surgery·Calvin S H Ng, Kelvin K W Lau
Aug 29, 2009·Asian Cardiovascular & Thoracic Annals·Calvin S H NgAnthony P C Yim
May 31, 2011·Yonsei Medical Journal·Jin Soo KimNam Kyu Kim
Dec 17, 2010·World Journal of Gastrointestinal Surgery·Carlo Staudacher, Andrea Vignali
Jun 27, 2019·World Journal of Gastrointestinal Oncology·Hmc Shantha KumaraRichard L Whelan
Aug 31, 2021·World Journal of Gastrointestinal Oncology·Hmc Shantha KumaraRichard L Whelan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.