Persistent endocrine stress response in patients undergoing cardiac surgery

Journal of Endocrinological Investigation
A Roth-IsigkeitP Schmucker

Abstract

To investigate the endocrine stress response in patients undergoing major surgery with general anesthesia using a balanced technique with sufentanil, isoflurane and midazolam up to the second postoperative day, blood levels of cortisol, epinephrine, norepinephrine, prolactin and growth hormone were determined in 68 males for elective coronary artery bypass grafting (CABG) surgery. Intraoperatively, during extracorporeal circulation none of the measured parameters were significantly increased compared to preoperative values. The endocrine response of patients with perioperative epinephrine medication (n = 32) was not significant different to patients that did not receive exogenous epinephrine (n = 36). On the evening of the day of surgery, levels of cortisol (3 fold), epinephrine (4.7 fold), norepinephrine (1.7 fold) and growth hormone (16.5 fold) were significantly increased. Compared to preoperative values levels of cortisol (3.3 fold), growth hormone (5.5 fold) and norepinephrine (1.8 fold) remained elevated up to the evening of the second postoperative day. In conclusion, the endocrine stress response in patients undergoing CABG-surgery under general anesthesia with sufentanil, midazolam, isoflurane is intraoperatively preve...Continue Reading

References

Jan 1, 1978·Acta Anaesthesiologica Scandinavica·M R BrandtH Kehlet
Mar 1, 1978·The British Journal of Surgery·S N MadsenA Engquist
Dec 1, 1979·Acta Anaesthesiologica Scandinavica·H Kehlet
Jul 1, 1976·Circulation·K M TaylorW H Bain
Apr 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·T H LiemJ van Egmond
Jun 1, 1990·British Journal of Anaesthesia·J P DesboroughS R Bloom
Jun 1, 1990·Journal of Cardiothoracic Anesthesia·K J TumanA D Ivankovich
Dec 4, 1990·Klinische Wochenschrift·G BenkerD Reinwein
Aug 1, 1990·Anesthesiology·C Weissman
Nov 1, 1989·The Journal of Clinical Endocrinology and Metabolism·M R WerbE B Marliss
Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Aug 1, 1988·The Journal of Clinical Endocrinology and Metabolism·C E WadeT H Jurney
Sep 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S M RazaE K Zsigmond
Jul 1, 1985·American Heart Journal·M WeiskopfR J Gray
Oct 21, 1972·Lancet·C P SalterL Stimmler
Oct 3, 1974·The New England Journal of Medicine·L I Goldberg
May 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J M GeorgeM Rower
Apr 1, 1983·Anesthesia and Analgesia·J G BovillD M Philbin
Jan 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J V FelicettaC J Goodner
Sep 1, 1982·Clinical Endocrinology·A Grossman, G M Besser
May 1, 1993·Journal of Gerontology·S L GreenspanD Elahi
Mar 1, 1993·Journal of Cardiac Surgery·D T Mangano
Feb 1, 1996·Endocrine Reviews·H O Besedovsky, A del Rey
Sep 1, 1996·Critical Care Medicine·G Van den Berghe, F de Zegher
Nov 1, 1996·Anesthesiology·A Herskowitz, D T Mangano

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Citations

Sep 21, 2010·Journal of Cardiothoracic and Vascular Anesthesia·William C OliverMartin D Abel
Feb 3, 2009·The American Journal of Medicine·Vineet ChopraKim A Eagle
Mar 31, 2007·Seminars in Thoracic and Cardiovascular Surgery·Athos J Rassias
Nov 28, 2006·The Annals of Thoracic Surgery·M Raschid HodaRaffaele De Simone
Mar 5, 2011·Cytometry. Part B, Clinical Cytometry·Jozsef BocsiAttila Tárnok
Jun 30, 2012·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Nabil Fallouh, Vineet Chopra
Mar 9, 2010·Current Problems in Surgery·Avihu Z GazitA Thomas Pezzella
Apr 26, 2006·Best Practice & Research. Clinical Anaesthesiology·Peter H TonnerJens Scholz
Sep 22, 2015·Frontiers in Surgery·Geoffrey P Dobson
Jun 12, 2004·Journal of Vascular Surgery·Massimiliano M Marrocco-TrischittaPaolo Guerrini
May 17, 2008·Journal of the American College of Cardiology·Don PoldermansHarm H Feringa
Oct 9, 1998·Clinical and Experimental Immunology·A Roth-IsigkeitM Seyfarth
Oct 3, 2000·Journal of Neurosurgery·K HirasawaT Hori
Aug 9, 2001·British Journal of Anaesthesia·H M SolimanJ L Vincent
Dec 18, 2001·Seminars in Surgical Oncology·T Weber, E Klar
Jul 9, 2005·Critical Care Medicine·Mark P YeagerPaul M Guyre
Nov 2, 2004·Der Anaesthesist·E SchaffrathP H Tonner
Oct 6, 2006·Current Opinion in Anaesthesiology·Peter H TonnerJens Scholz
Jul 1, 2004·Hemodialysis International·Władysław Sułowicz, Tomasz P Stompór
May 7, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Aymen N NaguibTimothy M Hoffman
Jun 9, 2001·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·V A HampshireR M Simpson
Apr 26, 2002·Anesthesia and Analgesia·Xiangyang GuoAlain Vuylsteke

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