Persistent gene expression changes in ventral tegmental area of adolescent but not adult rats in response to chronic nicotine.

Neuroscience
M B DouraD C Perry

Abstract

Because adolescent brains are undergoing extensive developmental changes, they may be uniquely sensitive to effects of addictive drugs like nicotine. We exposed adolescent and adult rats to nicotine infusion for two weeks, and then used whole genome microarray analysis to determine effects on gene expression in the ventral tegmental area. We examined brains immediately after two weeks of nicotine or saline, and also four weeks after termination of nicotine exposure. After identifying genes with a significant agextreatment interaction, we employed template matching to find specific patterns of expression across age and treatment. Of those genes that were transiently regulated (up- or down-regulated immediately following the end of nicotine treatment, but back to saline baseline 30 days later), two-thirds were specific to adult animals, while only 30% were specific to adolescents and 4% were shared across the two ages. In contrast, significant genes that were persistently regulated (altered following nicotine treatment and still altered 30 days later) were more likely (59%) to be adolescent, with only 32% in adults and 8% shared. The greatest number of significant genes was late-regulated (no change immediately after nicotine, bu...Continue Reading

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Citations

Jan 26, 2016·Neuropharmacology·Mai AlajajiM Imad Damaj
Dec 17, 2014·Molecular Neurobiology·Jean Lud Cadet
Dec 24, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Chiara FiorentiniCristina Missale
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Sep 21, 2019·The Western Journal of Emergency Medicine·Michelle Ren, Shahrdad Lotfipour
Feb 18, 2019·Biochemical Pharmacology·Carlo MateraClelia Dallanoce
Apr 9, 2021·Frontiers in Behavioral Neuroscience·Yasmine SherafatChristie D Fowler
Apr 10, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Desye Misganaw
Jun 10, 2021·Journal of Immigrant and Minority Health·Young S Seo, Yu-Ping Chang

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