PMID: 9552135Apr 29, 1998Paper

Persistent hepatitis G virus infection after neonatal transfusion

Journal of Pediatric Gastroenterology and Nutrition
J WoelfleM J Lentze

Abstract

Recently two Flaviviridae-like viruses have been discovered and named GB virus C and hepatitis G virus. Molecular characterization showed them to be different subtypes of the same virus. An association with posttransfusion hepatitis and with sporadic and fulminant hepatitis was reported, but most infected people remain asymptomatic. Data concerning hepatitis G virus infection in infants and children have not been reported to date. The prevalence of hepatitis G virus infection in children after transfusion of blood products in the neonatal period was studied. Serum samples from 251 children, who had received blood products in the first 4 weeks of life and who had been reexamined as part of another study at a mean interval of 37 months (range, 10-70) after last transfusion, were analyzed for hepatitis G virus infection. Follow-up examinations were performed in 14 of 19 hepatitis G virus-positive children 12 to 17 years after the last transfusion. Presence of hepatitis G virus RNA in serum was determined by a reverse transcription polymerase chain reaction assay with nested primers from the helicase region of the hepatitis G virus. To prove specificity of the hepatitis G virus, reverse transcription polymerase chain reaction assay...Continue Reading

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Citations

May 26, 2010·Transfusion·Flavien BernardinEric Delwart
Jun 19, 2012·Expert Review of Anti-infective Therapy·Carolynne Schwarze-ZanderJuergen K Rockstroh

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