Persistent high mortality in advanced HIV/TB despite appropriate antiretroviral and antitubercular therapy: an emerging challenge

Current HIV/AIDS Reports
Gregory P BissonRonald G Collman

Abstract

Approximately 1.1 million, or 13 %, of all TB cases in 2013 were coinfected with HIV, and in some African countries, such as Botswana and Swaziland, 60-80 % of TB cases are coinfected with HIV. Effective therapies for both HIV and TB exist, yet patients presenting with TB and advanced HIV still experience high rates of morbidity and mortality despite initiation of both antitubercular and antiretroviral therapy (ART). Previous reviews and research have focused largely on TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) as a type of complicated outcome on ART in advanced HIV/TB, but recent data indicate that immunologic failure despite suppressive ART is associated with early mortality. In this review, we examine recent findings regarding early mortality in HIV/TB and emerging concepts in the pathophysiology of TB-IRIS, in order to provide an integrated view of factors determining outcomes in coinfected people as well as highlight key needs for future research and therapeutic development.

References

Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
May 9, 2001·Blood·T J FryC L Mackall
Apr 19, 2003·American Journal of Respiratory and Critical Care Medicine·John L JohnsonUNKNOWN Uganda-Case Western Reserve University Research Collaboration
Jun 1, 1963·Tubercle·F A SIMMONDS
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph Keane
Feb 18, 2005·The Journal of Infectious Diseases·Harriet Mayanja-KizzaUNKNOWN Uganda-Case Western Research Collaboration
Jul 1, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charles B HolmesElena Losina
Sep 25, 2007·Tuberculosis·Helen McIlleronRobert J Wilkinson
Jul 12, 2008·BMJ : British Medical Journal·Andrew J NunnUNKNOWN UNZA-UCLMS Project LUCOT Collaboration
Jul 26, 2008·The Lancet Infectious Diseases·Graeme MeintjesUNKNOWN International Network for the Study of HIV-associated IRIS
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Graeme MeintjesRobert John Wilkinson
Feb 28, 2009·The Lancet Infectious Diseases·Michael J A Reid, N Sarita Shah
Apr 22, 2009·Blood·Irini SeretiUNKNOWN ACTG 5214 Study Team
Aug 7, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sebastiano LeoneNicola Acone
Sep 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne BourgaritUNKNOWN PARADOX Study Group
Nov 21, 2009·Clinics in Chest Medicine·Gavin J ChurchyardGraham A Rook
Mar 26, 2010·The Lancet Infectious Diseases·Monika MüllerUNKNOWN IeDEA Southern and Central Africa
Dec 1, 2010·The Journal of Experimental Medicine·Christof GeldmacherRichard A Koup
Jul 1, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·X-F GaoJ Li
Jul 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheryl L DayWillem A Hanekom
Sep 16, 2011·The Journal of Infectious Diseases·Michael M LedermanBenigno Rodriguez

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Citations

Feb 6, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tumaini J NaguFerdinand Mugusi
Apr 4, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Saskia JanssenGraeme Meintjes
Aug 18, 2020·Advances in Preventive Medicine·Getachew Seid, Marta Ayele
Feb 25, 2017·BMC Infectious Diseases·Aishatu L AdamuIbrahim Abubakar
Jul 28, 2019·Microbiology Spectrum·Gabriel T MashabelaDigby F Warner
Jul 9, 2021·Frontiers in Cellular and Infection Microbiology·Diego L CostaAlan Sher
Nov 5, 2021·Current HIV/AIDS Reports·Jason M Brenchley, Alexandra M Ortiz

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