Persistent high on-treatment platelet reactivity in acute coronary syndrome.

Journal of Thrombosis and Thrombolysis
Donald R LynchMarlene S Williams

Abstract

Persistent high on-treatment platelet reactivity in acute coronary syndrome (ACS) patients managed with appropriate antiplatelet therapy has been correlated with increased risk of cardiovascular events; however, the evolution of this phenomenon overtime is not well known. We investigated platelet activity at a three month follow-up after initial presentation with an ACS. We enrolled a total of 124 patients in the study, 65 were diagnosed with ACS and 59 controls who presented with non-cardiac chest pain for baseline comparisons. Of the enrolled patients, we had 25 ACS patients return, in stable condition, three months after their initial presentation for repeat platelet functional testing. Epinephrine (EPI), adenosine diphosphate (ADP), and arachidonic acid induced platelet aggregation were monitored at baseline with repeat measurement of EPI- and ADP-stimulated aggregation at follow-up. In addition, P-selectin and PAC-1 expression were monitored at presentation and at a three month follow-up period. ACS patients were maintained on aspirin therapy during the intervening period. At the three month follow-up visit, ACS patients initiated on aspirin had no significant percentage change in aggregation to submaximal concentrations o...Continue Reading

References

Dec 1, 1994·Stroke; a Journal of Cerebral Circulation·C M HelgasonL D Brace
Mar 19, 2004·Journal of the American College of Cardiology·Fabio M PulcinelliFrancesco Violi
Apr 16, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Denisa D Wagner
May 10, 2006·Journal of Thrombosis and Thrombolysis·Marlene S WilliamsDavid E Bush
Jun 8, 2007·Journal of Thrombosis and Thrombolysis·Andrew D AtiemoMarlene S Williams
Feb 5, 2008·International Journal of Cardiology·Francesco SofiGian Franco Gensini
Apr 3, 2009·Cleveland Clinic Journal of Medicine·Kandice Kottke-Marchant
Aug 14, 2009·European Journal of Clinical Investigation·J KempfertF W Mohr
Sep 11, 2010·Journal of the American College of Cardiology·Laurent BonelloUNKNOWN Working Group on High On-Treatment Platelet Reactivity

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Citations

Mar 9, 2017·Blood Pressure Monitoring·Sertac AlpaydinHaldun Muderrisoglu
Jun 16, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Cen ChenZhi-Ning Xia

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