Persistent histidine-rich protein 2, parasite lactate dehydrogenase, and panmalarial antigen reactivity after clearance of Plasmodium falciparum monoinfection

Journal of Clinical Microbiology
Jamshaid IqbalPersotum R Hira

Abstract

We tested 240 patients with Plasmodium falciparum monoinfection for persistent parasite antigenemia after successful standardized antimalarial therapy by using the ICT Malaria Pf/Pv and OptiMAL-IT assays that detect the malaria antigens Plasmodium falciparum histidine-rich protein 2 (HRP2) and parasite lactate dehydrogenase (pLDH), respectively, as well as a panmalarial antigen (PMA). The patients were screened for antigenemia on days 0, 3, 7, and 14 of follow-up. On day 0, all 240 patients showed positive reactivity with both assays. Of the 229 cases with negative parasitemia on day 3, persistent antigenemia was observed in 207 (90.4%) of the cases: 188 (82.1%) for HRP2 antigen and 75 (32.8%) for PMA. There was a gradual decrease in antigenemia on follow-up to day 14; however, the drop in reactivity to PMA was less than that for HRP2 antigen. In contrast to HRP2 antigenemia, there was a significant decrease in pLDH antigenemia to 38.4% and to 14.8% (PMA) on day 3 (P < 0.03). The pLDH antigenemia level dropped further to 14.8% on day 7. There was no significant association of persistent antigenemia with gametocytemia. One case with gametocytemia was negative for both the antigens. In conclusion, the OptiMAL-IT assay is more sen...Continue Reading

References

Sep 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·J KarbwangW Rooney
Jul 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·S VakhariaN A Kshirsagar
Jul 14, 1999·The American Journal of Tropical Medicine and Hygiene·R PriceN J White
Jul 18, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·D P Eisen, A Saul
Jan 2, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M E DyerN M Anstey
Jan 10, 2002·Clinical Microbiology Reviews·Anthony Moody
May 7, 2002·Annals of Tropical Medicine and Parasitology·S GattiUNKNOWN Lombardy Region's Study Group on International Health (SIRL)

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Citations

Jan 19, 2008·Clinical Microbiology Reviews·Clinton K MurrayR Scott Miller
Mar 12, 2010·Journal of Clinical Microbiology·Sharon WeinHenri Vial
Jul 3, 2010·The American Journal of Tropical Medicine and Hygiene·Joshua YukichChristian Lengeler
Feb 4, 2012·The American Journal of Tropical Medicine and Hygiene·Philip J Rosenthal
Apr 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ilse C E HendriksenArjen M Dondorp
Jul 10, 2014·BMC Infectious Diseases·Bonnie MeatherallDylan R Pillai
May 8, 2014·BioMed Research International·Priyamvada JainPranab Goswami
Jun 2, 2010·Clinics in Laboratory Medicine·Lynne S Garcia
Oct 23, 2009·Diagnostic Microbiology and Infectious Disease·Denise Patricia Mawili-MboumbaMaryvonne Kombila
Sep 13, 2014·Tropical Medicine & International Health : TM & IH
Sep 21, 2013·Journal of Medical Microbiology·Joel C Mouatcho, J P Dean Goldring
Feb 27, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J MalthaJ Jacobs
Mar 5, 2016·PLoS Neglected Tropical Diseases·Saskia DecuypereJonathan R Carapetis
Jun 22, 2016·The American Journal of Tropical Medicine and Hygiene·Jonathan B ParrJonathan J Juliano
Aug 12, 2015·The American Journal of Tropical Medicine and Hygiene·Tamaki KobayashiJoseph M Vinetz
Mar 24, 2016·The American Journal of Tropical Medicine and Hygiene·Cécile NabetRenaud Piarroux
Sep 26, 2013·The American Journal of Tropical Medicine and Hygiene·Sean C MurphyV Ann Stewart
May 20, 2017·BMC Public Health·Matthew R Boyce, Wendy P O'Meara
Dec 19, 2014·The Cochrane Database of Systematic Reviews·Katharine AbbaYemisi Takwoingi
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Katharine AbbaPaul Garner
Apr 23, 2011·Blood·Matthew NdonwiDaniel E Goldberg
Jul 10, 2019·The Korean Journal of Parasitology·Yousry HawashWalaa Alsanie
Jul 7, 2017·Science Translational Medicine·Papa Alioune NdourUNKNOWN French Artesunate Working Group

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