Persistent 'hotspots' of lymphatic filariasis microfilaraemia despite 14 years of mass drug administration in Ghana

Transactions of the Royal Society of Tropical Medicine and Hygiene
Nana-Kwadwo BiritwumJoseph B Koroma

Abstract

Among the 216 districts in Ghana, 98 were declared endemic for lymphatic filariasis in 1999 after mapping. Pursuing the goal of elimination, WHO recommends annual treatment using mass drugs administration (MDA) for at least 5 years. MDA was started in the country in 2001 and reached national coverage in 2006. By 2014, 69 districts had 'stopped-MDA' (after passing the transmission assessment survey) while 29 others remained with persistent microfilaraemia (mf) prevalence (≥1%) despite more than 11 years of MDA and were classified as 'hotspots'. An ecological study was carried out to compare baseline mf prevalence and anti-microfilaria interventions between hotspot and stopped-MDA districts. Baseline mf prevalence was significantly higher in hotspots than stopped-MDA districts (p<0.001). After three years of MDA, there was a significant decrease in mf prevalence in hotspot districts, but it was still higher than in stopped-MDA districts. The number of MDA rounds was slightly higher in hotspot districts (p<0.001), but there were no differences in coverage of MDA or long-lasting-insecticide-treated nets. The main difference in hotspots and stopped-MDA districts was a high baseline mf prevalence. This finding indicates that the reco...Continue Reading

References

Dec 16, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·J O GyapongR H Webber
Apr 6, 2005·Tropical Medicine & International Health : TM & IH·Aiah A GbakimaAlan L Scott
Oct 9, 2008·PLoS Neglected Tropical Diseases·Eric A OttesenGautam Biswas

Citations

Jan 18, 2019·PLoS Neglected Tropical Diseases·Peter J HotezJeffrey D Sachs
Sep 18, 2018·PLoS Neglected Tropical Diseases·Andres GarchitorenaHolivololona Rabenantoandro
Jun 6, 2018·Parasites & Vectors·Joseph B KoromaYaobi Zhang
Dec 22, 2019·Scientific Reports·Joseph R FauverPeter U Fischer
Dec 29, 2020·PLoS Neglected Tropical Diseases·Yakuba M BahYaobi Zhang

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