Persistent hypoglycemia is induced by tolbutamide administration in broiler chickens fed a low-carbohydrate diet

Domestic Animal Endocrinology
Y SekiY Akiba

Abstract

With a view to gaining an insight into the regulatory mechanism of blood glucose concentrations specific to the chicken, an experimental induction of hypoglycemia was conducted by single or sequential administration of tolbutamide in broiler chickens fed a standard or low-carbohydrate diet. A single dosing of tolbutamide at levels of 25-200 mg/kg body weight decreased plasma glucose concentrations for 2 to 8 h after the dosing in chickens fed either diet. No significant rise in plasma insulin concentration was observed for 2 to 24 h after the single dosing of tolbutamide in chickens on either diet, with the exception of a significant rise when chickens on the standard diet received 100 mg tolbutamide. However, a transient increase of plasma insulin concentration was observed only in the 20 min immediately after the single dosing. Persistent hypoglycemia that was sustained for 5 days, with no significant changes in plasma insulin concentration, was induced by sequential dosing (3 times per day for 5 days, every 8 h) of tolbutamide (100 and 200 mg/kg body weight) in chickens fed the low-carbohydrate diet. In these chickens, the consistently low concentration of plasma glucose, with small diurnal variations, was evidenced by the d...Continue Reading

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Citations

Aug 6, 2003·General and Comparative Endocrinology·Yoshinori SekiYukio Akiba
Feb 18, 2004·British Poultry Science·Y TokushimaY Akiba
Aug 30, 2011·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sergio PolakofJosé L Soengas
Jun 24, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Eldon J Braun, Karen L Sweazea
Jun 24, 2011·IUBMB Life·Zhong-Wei ZhangShu Yuan
Jun 16, 2018·Journal of Avian Medicine and Surgery·Peter M DiGeronimoDawn E Evans
Apr 1, 2008·Molecular and Cellular Biochemistry·Monika Proszkowiec-WeglarzMark P Richards
Aug 10, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yoshinori SekiYukio Akiba

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