PMID: 8614557Nov 17, 1995Paper

Persistent increase in dopamine release following activation of metabotropic glutamate receptors in the rat nucleus accumbens

Neuroscience Letters
M Ohno, S Watanabe

Abstract

Intracerebral microdialysis technique was utilized to study the effect of the metabotropic glutamate receptor agonist, 1-aminocyclopentane-1,3-dicarboxylic acid (ACDP), on extracellular dopamine concentration in the nucleus accumbens of unanesthetized, freely moving rats. Perfusion of 1 mM (1S, 3R)-ACPD, a selective metabotropic glutamate receptor agonist, through the microdialysis probe caused a significant and persistent increase in extracellular dopamine level in the nucleus accumbens, which disappeared 2 h after perfusion of (1S, 3R)-ACPD was discontinued. On the other hand, a temporary increase in dopamine overflow was observed when 1 and 3 mM N-methyl-D-aspartate (NMDA), an ionotropic glutamate receptor agonist, was perfused into the nucleus accumbens. Application of 1 mM (1R, 3S)-ACPD, an inactive isomer, into the nucleus accumbens had no effect on the extracellular dopamine concentration. The metabotropic glutamate receptor antagonist, alpha-methyl-4-carboxyphenylglycine (MCPG) (5 mM) did not affect the basal dopamine level, but it attenuated the (1S, 3R)-ACPD-evoked dopamine overflow in the nucleus accumbens when applied concurrently with 1 mM (1S, 3R)-ACPD. These results suggest that a long-lasting dopamine overflow f...Continue Reading

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Citations

Feb 1, 1997·Psychopharmacology·I M MaisonneuveS D Glick
Apr 17, 1999·European Journal of Pharmacology·R K BrutonN M Barnes
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·P J Kenny, A Markou
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Dec 4, 2001·Brain Research. Molecular Brain Research·V LilliuC Perrone-Capano

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