Persistent increased threshold of electrical stimulation selective to motor nerve in multifocal motor neuropathy

Muscle & Nerve
T YokotaH Tanaka

Abstract

In multifocal motor neuropathy (MMN) the threshold of electrical stimulation showed a persistent, marked increase for the motor nerve which decreased after treatment with intravenous immunoglobulin or oral cyclophosphamide; whereas, the threshold was normal for the sensory nerve. This discrepancy of the thresholds for motor and sensory nerves indicates that the increased threshold for motor nerve is not caused by change in perineural capacitance, such as subperi- and endoneural edema or perineural thickening. Inching studies showed that the site of the elevated motor nerve threshold was closely associated with conduction slowing and block. For the cause of the increased threshold, therefore, we suppose the presence of a factor which interferes with reorganization of the nodal property in the remyelinative process or which directly blocks sodium channels where the blood-nerve barrier is impaired in MMN.

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Citations

Jan 20, 2000·Muscle & Nerve·P Y Van den BerghE C Laterre
Apr 5, 2002·Muscle & Nerve·Akira InabaHidehiro Mizusawa
Oct 12, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A InabaH Mizusawa
Mar 4, 2000·American Journal of Physical Medicine & Rehabilitation·T Y Chuang, F Y Chiou-Tan
Jun 30, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Suraj Ashok Muley, Gareth J Parry
Mar 17, 2005·Muscle & Nerve·Eduardo Nobile-OrazioAlberto Priori
Oct 19, 2011·Journal of the Peripheral Nervous System : JPNS·Susanna B ParkMatthew C Kiernan
Jul 29, 2015·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Dimitra Veltsista, Elisabeth Chroni
Mar 2, 2002·Brain : a Journal of Neurology·Matthew C KiernanHugh Bostock
Jul 16, 2002·Annual Review of Biomedical Engineering·Wim L C Rutten
May 13, 2005·Brain : a Journal of Neurology·Alberto PrioriSergio Barbieri
Apr 23, 2005·The Cochrane Database of Systematic Reviews·I N van SchaikM Vermeulen

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