Persistent increases in basal cerebral metabolic activity induced by morphine sensitization

Pharmacology, Biochemistry, and Behavior
M A KrausC Kornetsky

Abstract

To characterize the underlying neuroanatomic substrate of morphine (MS) sensitization, changes in the local cerebral metabolic rate for glucose (LCMRglu) were examined in 95 brain regions of male F-344 rats using the 2-deoxy-D-[1-14C]glucose method. The results of these experiments demonstrate that MS-induced sensitization is manifested by increases in basal metabolic activity that last for at least 6 days. Although changes in basal metabolic rate were found to be more extensive in the presence of conditioned cues, the increases in LCMRglu in nonconditioned sensitized rats indicate a basic underlying pharmacologic effect of MS sensitization on basal brain activity. Regions in which MS sensitization had a lasting pharmacologic effect include the shell of the nucleus accumbens, the prelimbic area of the prefrontal cortex, and the dorsolateral prefrontal cortex. Interestingly, the core of the nucleus accumbens and regions of the caudate were found to have an increased LCMRglu only in the presence of conditioned cues, indicating conditioned brain activity without observable changes in behavior. The previous administration of an MS-sensitizing treatment was also found to alter the cerebral metabolic response to a subsequent acute MS...Continue Reading

References

Jan 1, 1975·The Journal of Pharmacy and Pharmacology·A L Gough, J E Olley
Jun 28, 1992·Annals of the New York Academy of Sciences·M A NaderJ E Barrett
Jun 28, 1992·Annals of the New York Academy of Sciences·R M PostA Pert
Oct 31, 1991·Biochemical and Biophysical Research Communications·Y SasakiK Suzuki
Dec 15, 1990·The Journal of Comparative Neurology·D S Zahm, L Heimer
Jun 28, 1991·Brain Research·R KarlerS A Turkanis
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F SchuierL Sokoloff
Dec 1, 1989·Behavioral Neuroscience·B A Mattingly, J E Gotsick
Jan 1, 1989·Life Sciences·R KarlerS A Turkanis
Jul 31, 1989·Neuroscience Letters·J Pollock, C Kornetsky
Apr 15, 1987·The Journal of Comparative Neurology·T A FullerJ L Price
Jun 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F OrziL Sokoloff
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·P Vezina, J Stewart
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G F WootenR C Collins
Aug 1, 1980·Journal of Neurochemistry·H E SavakiL Sokoloff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.