Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jan Steffen JürgensenKai-Uwe Eckardt

Abstract

Hypoxia-inducible factor (HIF)-1alpha and -2alpha are key regulators of the transcriptional response to hypoxia and pivotal in mediating the consequences of many disease states. In the present work, we define their temporo-spatial accumulation after myocardial infarction and systemic hypoxia. Rats were exposed to hypoxia or underwent coronary artery ligation. Immunohistochemistry was used for detection of HIF-1alpha and -2alpha proteins and target genes, and mRNA levels were determined by RNase protection. Marked nuclear accumulation of HIF-1alpha and -2alpha occurred after both systemic hypoxia and coronary ligation in cardiomyocytes as well as interstitial and endothelial cells (EC) without pronounced changes in HIF mRNA levels. While systemic hypoxia led to widespread induction of HIF, expression after coronary occlusion occurred primarily at the border of infarcted tissue. This expression persisted for 4 wk, included infiltrating macrophages, and colocalized with target gene expression. Subsets of cells simultaneously expressed both HIF-alpha subunits, but EC more frequently induced HIF-2alpha. A progressive increase of HIF-2alpha but not HIF-1alpha occurred in areas remote from the infarct, including the interventricular s...Continue Reading

References

Sep 1, 1996·Molecular and Cellular Biology·J A ForsytheG L Semenza
Apr 1, 1999·Annual Review of Physiology·T Miyauchi, T Masaki
Dec 29, 1999·Nature Medicine·J LiM Simons
Mar 4, 2000·The New England Journal of Medicine·S H LeeP A Thistlethwaite
Jun 6, 2000·The Journal of Biological Chemistry·D E RichardJ Pouyssegur
Oct 6, 2000·The Journal of Clinical Investigation·R S Williams, I J Benjamin
Oct 6, 2000·Current Opinion in Plant Biology·A Massiah
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·I KetolaM Heikinheimo
Apr 9, 2001·Science·H Zhu, H F Bunn
Jun 12, 2001·Cardiovascular Research·R J Bing
Oct 13, 2001·Science·R K Bruick, S L McKnight
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D M StrokaD Candinas
Feb 2, 2002·Science·David LandoMurray L Whitelaw
Apr 24, 2002·Seminars in Cell & Developmental Biology·Patrick H Maxwell, Peter J Ratcliffe
Jun 25, 2002·Genes & Development·William G Kaelin
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Christian RosenbergerKai-Uwe Eckardt
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amanda W WyattGiovanni E Mann
Dec 20, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael S WiesenerKai-Uwe Eckardt
Mar 12, 2003·Cell·Thorsten CramerRandall S Johnson

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Citations

Feb 9, 2008·Cell Death and Differentiation·S A Patel, M C Simon
Nov 7, 2008·Nature Reviews. Cancer·Jessica A BertoutM Celeste Simon
Nov 28, 2012·International Immunology·Elena RiboldiAntonio Sica
Mar 21, 2009·Clinical and Experimental Pharmacology & Physiology·Tao TanHarvey R Weiss
Sep 24, 2008·Nephrology·Jorge Eduardo ToblliHasan Kulaksiz
Apr 28, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuhua WangWenke Feng
Aug 4, 2011·PloS One·Marta Miró-MurilloJulián Aragonés
Jan 24, 2013·International Journal of Molecular Sciences·Ina Berniakovich, Marco Giorgio
Jun 8, 2017·International Journal of Molecular Sciences·Chung-Wen KuoChia-Wei Liou
Aug 9, 2012·Antioxidants & Redox Signaling·Clement CochainJean-Sébastien Silvestre
Jul 8, 2014·Antioxidants & Redox Signaling·Wataru KimuraHesham A Sadek
Nov 16, 2012·Circulation·Chris JoplingJuan Carlos Izpisua Belmonte
Jan 18, 2005·The Journal of Biological Chemistry·Cameron P BrackenDaniel J Peet
Nov 21, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ralph V Shohet, Joseph A Garcia
Feb 9, 2008·Cell Death and Differentiation·G Loor, P T Schumacker
Feb 28, 2009·European Journal of Anaesthesiology·Stefanie HieberBenedikt Preckel
Dec 22, 2006·Journal of the American Society of Nephrology : JASN·Christian RosenbergerPetra Reinke
Sep 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Sebastian PhilippJames M Downey
Mar 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ryon M BatemanKeith R Walley
Jun 23, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Gregori CasalsWladimiro Jiménez
Apr 23, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gadi BorkowMoshe Marikovsky
Dec 12, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Simon X Liang, William D Phillips
Aug 31, 2013·Annual Review of Physiology·Gregg L Semenza
Jun 24, 2017·The EMBO Journal·Brian W WongPeter Carmeliet
Feb 6, 2014·Current Treatment Options in Cardiovascular Medicine·Laurent GambaChing-Ling Lien
Feb 29, 2008·The Journal of Pharmacology and Experimental Therapeutics·Amina ArabChristoph Hehrlein
May 30, 2017·Expert Opinion on Therapeutic Targets·Shi-Yang GuanHai-Feng Pan
Jan 17, 2020·Journal of Cellular Physiology·Mattia CriscuoliAntonella Naldini
Mar 10, 2020·Experimental Biology and Medicine·Ying XiaoY James Kang

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