Abstract
Some infarcts have persistently hyperintense areas on diffusion-weighted MRI (DWI) even at 1 month after stroke, whereas others have become isointense to normal brain. We hypothesized that late DWI hyperintensity reflected different infarct evolution compared with areas that were isointense by 1 month. We recruited patients prospectively with ischemic stroke, performed DWI and perfusion-weighted MRI (PWI) on admission, at 5 days, 14 days, and 1 month after stroke, and assessed functional outcome at 3 months (Rankin Scale). Patient characteristics and DWI/PWI values were compared for patients with or without "still hyperintense" infarct areas on 1-month DWI. Among 42 patients, 27 (64%) had "still hyperintense" infarct regions at 1 month, mostly in white matter. Patients with "still hyperintense" regions at 1 month had lower baseline apparent diffusion coefficient ratio (ADCr; mean+/-SD 0.76+/-0.12 versus 0.85+/-0.12; hyperintense versus isointense; P<0.05), prolonged reduction of ADCr (repeated-measures ANOVA; P<0.01), no difference in baseline perfusion but delayed normalization of mean transit time (P<0.05) and cerebral blood flow ratios (repeated measures ANOVA; P<0.05), initially more severe stroke, and worse 3-month outcome...Continue Reading
References
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D HeissK Wienhard
Jun 22, 1991·Lancet·J BamfordC Warlow
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Feb 1, 1995·Annals of Neurology·S WarachR R Edelman
Nov 1, 1995·NMR in Biomedicine·M E MoseleyA de Crespigny
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L OstergaardB R Rosen
Jul 1, 1997·Neurology·G SchlaugS Warach
Sep 2, 1998·AJR. American Journal of Roentgenology·J H BurdetteA D Elster
Aug 3, 1999·Radiology·J H BurdetteP E Ricci
Apr 13, 2000·Neurology·W Hacke, S Warach
May 1, 2001·Neuroradiology·B GeijerS Holtås
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
May 20, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·U G R SchulzP M Rothwell
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·Steven Warach, Lawrence L Latour
Oct 27, 2004·Annals of Neurology·Antonio L E FalcaoGeoffrey A Donnan
Nov 19, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·S Muñoz ManiegaJ M Wardlaw
Mar 30, 2005·Cerebrovascular Diseases·Carly S Rivers, Joanna M Wardlaw
Citations
Jul 25, 2008·Neuroradiology·Kentaro AkazawaTsunehiko Nishimura
Nov 30, 2010·Neuroradiology·Thomas RitzenthalerNorbert Nighoghossian
Jun 19, 2009·Journal of Neurology·I KaneJ M Wardlaw
Jan 16, 2010·Medical & Biological Engineering & Computing·David N KennedyVerne S Caviness
Mar 6, 2012·Translational Stroke Research·Loren E GloverCesar V Borlongan
Nov 8, 2012·PloS One·Magdalena ChechlaczGlyn W Humphreys
Apr 10, 2009·AJNR. American Journal of Neuroradiology·P G Kranz, J D Eastwood
Jun 29, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kate Lykke LambertsenBente Finsen
May 9, 2008·Experimental Neurology·Jeffrey J LegosFrank C Barone
May 28, 2009·Journal of Magnetic Resonance Imaging : JMRI·Igor SibonVincent Dousset
Oct 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Rüdiger J Seitz, Geoffrey A Donnan
Feb 24, 2010·Journal of Internal Medicine·J M Wardlaw
Nov 19, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Moran ArtziUNKNOWN STIR and VISTA Imaging collaborators
May 6, 2014·Health Technology Assessment : HTA·Joanna WardlawMartin Dennis
Jul 25, 2012·Computer Methods and Programs in Biomedicine·Fan ZhuJoanna Wardlaw
Dec 27, 2011·Journal of Korean Neurosurgical Society·Seungnam SonByeong Hoon Lim
Sep 30, 2016·AJR. American Journal of Roentgenology·William T C YuhNorman J Beauchamp
Jan 21, 2016·Stroke; a Journal of Cerebral Circulation·Stephen D J Makin, Joanna M Wardlaw
Nov 30, 2018·Acta Neuropathologica·Kate Lykke LambertsenBettina Hjelm Clausen
Feb 14, 2021·Neuroradiology·Lakshini GunasekeraBernard Yan
Jun 10, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Kim WiegertjesJoanna M Wardlaw
Aug 17, 2021·Topics in Magnetic Resonance Imaging : TMRI·Varsha MuddasaniMatthew D Alexander