PMID: 2117071Sep 1, 1990Paper

Persistent infection of rhesus macaques with a molecular clone of human immunodeficiency virus type 2: evidence of minimal genetic drift and low pathogenetic effects

Journal of Virology
G FranchiniF Wong-Staal

Abstract

In an attempt to generate a suitable animal model to study the infectivity and possible pathogenicity of human immunodeficiency viruses, we intravenously inoculated juvenile rhesus macaques and African green monkeys with a molecularly cloned virus, human immunodeficiency virus type 2 HIV-2sbl/isy, as well as with the uncloned HIV-2nih-z virus. Infection was monitored by virus recovery from the peripheral blood cells and by seroconversion against HIV-2 antigens measured by Western immunoblot, radioimmunoprecipitation, and enzyme-linked immunosorbent assay. We successfully infected two out of two macaques with the molecularly cloned virus and one macaque out of two with the HIV-2nih-z. No evidence of infection was seen in the African green monkeys with either virus. We followed the infected animals for 2 years. The animals remained healthy, although we observed intermittent lymphadenopathy and a transient decrease in the absolute number of circulating CD4+ T lymphocytes in both animals infected with the molecularly cloned virus. Virus isolation from the peripheral blood cells of the infected animals was successful only within the first few months after inoculation. Evidence of persistent infection was provided by the detection of...Continue Reading

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Citations

Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z HelG Franchini
Feb 1, 1994·Journal of Medical Primatology·S GartnerG A Eddy
Mar 1, 1995·AIDS Research and Human Retroviruses·A G AbimikuM Robert-Guroff
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zdenek HelGenoveffa Franchini
Sep 6, 2019·AIDS Research and Therapy·Joakim EsbjörnssonChristian Wejse
Feb 7, 1998·AIDS Research and Human Retroviruses·G KrausD J Looney
Sep 1, 1994·AIDS Research and Human Retroviruses·G Franchini, M S Reitz
Jan 1, 1996·American Journal of Primatology·Lillian Maggio-PriceAngelika Grossmann
Jun 1, 1995·Journal of Virology·S MatsushitaK Takatsuki
Aug 1, 1992·Antiviral Research·J A Koch, R M Ruprecht
Sep 1, 1992·Journal of Virology·R E UngerP A Luciw

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