PMID: 9660071Jul 11, 1998Paper

Persistent infection with an influenza C virus variant is dominantly established in the presence of the parental wild-type virus

Virus Research
M MarschallH Meier-Ewert

Abstract

Two influenza C viruses were used for double-infection experiments to investigate the dominance of their phenotypes. The wild-type virus (C/AA-wt) had been characterized by its short-lived productive cycle, whereas a distinct variant derived from it (C/AA-pi) was demonstrated to persist in long-term passages of infected MDCK cultures. Here we show that the persistent virus C/AA-pi is capable of replicating in the presence of abundant amounts of wild-type virus: the persistent virus could be diluted to 10(-9) within wild-type inoculum, still developing a stable form of persistence. This behaviour was reflected by permanent virus release and by continuous enzymatic activity of the viral HEF glycoprotein in infected cells. All long-term cultures tested remained positive for viral NS protein and vRNA. On the vRNA level, it was shown that viral segments originated from the persistent-type genome, while wild-type vRNAs were not maintained after double-infection. Thus, the genotype of the persistent variant was dominantly selected in serial passages. These results indicate a specific intracellular advantage of persistent influenza C virus over the parental wild-type.

References

Dec 1, 1989·The Journal of General Virology·F Y Goshima, K Maeno
Sep 1, 1994·The Journal of General Virology·M MarschallH Meier-Ewert
Mar 1, 1995·Journal of Virological Methods·M MarschallH Meier-Ewert
Dec 1, 1994·The Journal of General Virology·G PengK Nakamura
Jul 1, 1993·Virus Research·A C ClavoM W Shaw
Jan 1, 1993·Journal of Virological Methods·J C ManuguerraJ S Robertson
Jul 1, 1996·The Journal of General Virology·G PengK Nakamura
Feb 1, 1996·Journal of Virological Methods·S SakamotoF Maassab

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Citations

Jun 27, 2008·Journal of Virology·Michael KrasnitzRaul Rabadan

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