Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis

The Journal of Infectious Diseases
B KahlG Peters

Abstract

In a 34-month prospective study to determine the prevalence of Staphylococcus aureus small colony variants (SCVs) in cystic fibrosis (CF) patients, S. aureus SCVs or SCVs plus normal S. aureus were recovered from 26 of 78 patients; 27 patients harbored only normal S. aureus. By pulsed-field gel electrophoresis, clonal identity was demonstrated of SCV and normal strains isolated at the same time and of multiple S. aureus SCV and normal strains in consecutive specimens from individual patients. All S. aureus SCVs were resistant to antifolate antibiotics, while the corresponding parent strains were susceptible, and in 11 of 12 SCV/normal pairs, gentamicin was less active against S. aureus with the SCV phenotype than against the normal isolate. Analysis of the underlying auxotrophism of SCVs revealed hemin, thymidine, and/or menadione dependencies. Thus, S. aureus SCVs are highly prevalent in respiratory secretions of CF patients, persist over extended periods, and may contribute to S. aureus persistence in CF patients.

Citations

Mar 27, 2010·The Journal of Membrane Biology·Beatrix Vécsey-SemjénRoland Möllby
Jan 22, 2011·Folia Microbiologica·O Melter, B Radojevič
Sep 19, 2003·The Journal of Surgical Research·D J HessC L Wells
Feb 28, 2003·Lancet·Felix Ratjen, Gerd Döring
Mar 18, 2000·International Journal of Antimicrobial Agents·P J McNamara, R A Proctor
Apr 6, 2002·FEMS Immunology and Medical Microbiology·Beata SadowskaBarbara Róźalska
Jan 5, 2000·Microbes and Infection·M L Hutchison, J R Govan
Aug 4, 1999·Molecular Medicine Today·B Tümmler, C Kiewitz
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·N RendersA Van Belkum
Jun 17, 2011·Animal Health Research Reviews·Heba AtallaBonnie Mallard
Mar 17, 2006·Nature Reviews. Microbiology·Richard A ProctorGeorg Peters
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C von EiffG Peters
Sep 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Parham SendiWerner Zimmerli
May 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rachel J Gordon, Franklin D Lowy
Nov 13, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Rashad AlkasirBo Han
Mar 24, 2009·The Journal of Antimicrobial Chemotherapy·Damir BegicBrian T Tsuji
Sep 29, 2011·The Journal of Antimicrobial Chemotherapy·Evgeny A IdelevichKarsten Becker
Mar 15, 2013·The Journal of Antimicrobial Chemotherapy·Laetitia G GarciaFrançoise Van Bambeke
Mar 11, 2005·Journal of Clinical Gastroenterology·Nelson L Turcios
Mar 2, 2011·Antimicrobial Agents and Chemotherapy·Gabriel MitchellFrançois Malouin
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Joe LatimerAndrew J McBain
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Anne-Laure PrunierRoland Leclercq
Jan 15, 2011·Clinical Microbiology Reviews·Alan R HauserSusanna A McColley
Dec 28, 2007·Infection and Immunity·Johannes ZanderThomas A Wichelhaus
Jun 24, 2003·Infection and Immunity·David A CanoFrancisco García-del Portillo
Mar 25, 2004·Infection and Immunity·Andreas RoggenkampMathias W Hornef
Jan 24, 2006·Infection and Immunity·Costi D SifriChristof von Eiff

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