Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain

International Journal of Molecular Sciences
Austin ChouSusanna Rosi

Abstract

Traumatic brain injury (TBI) is a leading cause for neurological disabilities world-wide. TBI occurs most frequently among the elderly population, and elderly TBI survivors suffer from reduced recovery and poorer quality of life. The effect of age on the pathophysiology of TBI is still poorly understood. We previously established that peripherally-derived monocytes (CCR2⁺) infiltrate the injured brain and contribute to chronic TBI-induced cognitive deficits in young animals. Furthermore, age was shown to amplify monocyte infiltration acutely after injury. In the current study, we investigated the impact of age on the subchronic response of peripherally-derived monocytes (CD45hi; CCR2⁺) and their role in the development of chronic cognitive deficits. In the aged brain, there was a significant increase in the number of peripherally-derived monocytes after injury compared to young, injured animals. The infiltration rate of peripherally-derived monocytes remained elevated subchronically and corresponded with enhanced expression of CCR2 chemotactic ligands. Interestingly, the myeloid cell populations observed in injured aged brains had impaired anti-inflammatory responses compared to those in young animals. Additionally, in the aged...Continue Reading

References

Jan 1, 1988·Journal of Neurotrauma·J W Lighthall
Nov 24, 1999·Brain Research. Developmental Brain Research·F AlliotB Pessac
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
May 22, 2003·Progress in Neurobiology·Ephron S Rosenzweig, Carol A Barnes
Oct 22, 2003·Journal of Neurosurgery·Chantal W P M HukkelhovenAndrew I R Maas
Mar 23, 2007·Journal of Neurotrauma·Nino A MushkudianiAndrew I R Maas
Nov 21, 2007·Nature Neuroscience·Bahareh AjamiFabio M V Rossi
Jul 25, 2009·Journal of Neurotrauma·Michael SchönbergerRichard O'Sullivan
Dec 24, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bridgette D SempleM Cristina Morganti-Kossmann
Feb 6, 2010·Science·Frederic GeissmannKlaus Ley
Mar 11, 2010·Nature Reviews. Neuroscience·Victoria E JohnsonDouglas H Smith
Mar 18, 2010·The Journal of Head Trauma Rehabilitation·John D CorriganJean A Langlois Orman
Jun 18, 2010·Journal of Neuroimmunology·Marco Prinz, Josef Priller
Oct 11, 2011·Nature Reviews. Immunology·Chao Shi, Eric G Pamer
Jan 10, 2012·Journal of Neurotrauma·Nino StocchettiAngelo Colombo
Jun 19, 2012·BMC Immunology·Dapeng GongNora Heisterkamp
Jun 26, 2012·Brain, Behavior, and Immunity·Alok Kumar, David J Loane
Aug 13, 2013·Journal of Molecular Neuroscience : MN·Su LiuTong Wang
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Josh M MorgantiSusanna Rosi
Sep 8, 2015·Experimental Neurology·David J Loane, Alok Kumar
Oct 22, 2015·Journal of Neurotrauma·Alok KumarDavid J Loane
Nov 21, 2015·Biochimica Et Biophysica Acta·Michael GliemSebastian Jander
Nov 26, 2015·Frontiers in Neurology·Jon HazeldineAntonio Belli
Dec 5, 2015·Journal of Neuroinflammation·Stefka GyonevaRichard M Ransohoff
Dec 25, 2015·PloS One·Kyle A JablonskiMireia Guerau-de-Arellano
Apr 15, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Somsak WattananitZaal Kokaia
Apr 20, 2016·Journal of Neuroinflammation·Josh M MorgantiSusanna Rosi
May 18, 2016·Neuroscience and Biobehavioral Reviews·Keisuke KawataDianne Langford
May 26, 2016·Journal of Neuroinflammation·Charles C KimChristine L Hsieh
Oct 6, 2017·Brain Injury : [BI]·Denes V AgostonElaine R Peskind

❮ Previous
Next ❯

Citations

Apr 16, 2020·Journal of Neuroinflammation·Alexandria N EarlyJosh M Morganti
Nov 15, 2019·Neurorehabilitation and Neural Repair·Aiwane IboayaRandolph J Nudo
Sep 12, 2020·Nature Communications·Ashley C BolteJohn R Lukens
Jan 28, 2019·Journal of Neuroinflammation·Alex P Di BattistaMichael G Hutchison
Nov 30, 2018·International Journal of Molecular Sciences·Karen KrukowskiSusanna Rosi
Oct 19, 2020·Molecular Neurodegeneration·Karim BelarbiMarie-Christine Chartier-Harlin
Jan 27, 2021·Trends in Neurosciences·Alan I FadenRebecca J Henry
Oct 18, 2020·Molecular and Cellular Neurosciences·Jack Reddaway, Nichola M Brydges
Dec 9, 2020·Thrombosis Research·W Brad HubbardRolando E Rumbaut
Dec 16, 2020·International Journal of Molecular Sciences·Michela CampoloIrene Paterniti
Nov 17, 2020·GeroScience·Melod MehdipourIrina M Conboy
Jul 3, 2021·Journal of Neurotrauma·Douglas H SmithFiona Crawford
Dec 3, 2021·Neurology and Therapy·Jiangtao ShengKangsheng Li

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
Knockout
flow cytometry
FACS
PCR

Software Mentioned

Ethovision
Treestar
FlowJo
Transnetyx
Graphpad Prism

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.