Persistent inflammation and recovery after intensive care: A systematic review.

Journal of Critical Care
David M GriffithTimothy S Walsh

Abstract

Physical weakness is common after critical illness; however, it is not clear how best to treat it. Inflammation characterizes critical illness, is associated with loss of muscle mass during critical illness, and potentially modifies post-intensive care unit (ICU) recovery. We sought to identify published reports on the prevalence of systemic inflammation after critical illness and its association with physical recovery. This is a systematic review of the literature from MEDLINE, EMBASE, CINAHL, CPCI-SSH, and CPCI-S from January 1982 to December 2011. From 7433 references, 207 full-text articles were reviewed, 57 were eligible, and 22 were included. Inflammation was present in most patients at ICU discharge according to C-reactive protein concentration (range, 70%-100%), procalcitonin (range, 89%-100%), tumor necrosis factor α (100%), and systemic inflammatory response syndrome criteria (range, 92%-95%). Fewer patients had elevated myeloperoxidase concentrations (range, 0%-56%). At hospital discharge, 9 (90%) of 10 chronic obstructive pulmonary disease patients had elevated C-reactive protein. No studies tested the association between inflammation and physical recovery. Inflammation is present in most patients at ICU discharge, ...Continue Reading

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Citations

Aug 5, 2016·Thorax·Doug Elliott, Zudin Puthucheary
Jan 3, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Jens Kondrup
Mar 25, 2020·Journal of Intensive Care Medicine·Matthew A WarnerDale M Needham
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Aug 19, 2017·Annals of the American Thoracic Society·Marina MourtzakisZudin Puthucheary
Nov 4, 2020·American Journal of Respiratory and Critical Care Medicine·Ann M ParkerDale M Needham
Mar 17, 2021·Acta Anaesthesiologica Scandinavica·Emily BrückPeder S Olofsson

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