Persistent Low Level of Hepatitis B Virus Promotes Fibrosis Progression During Therapy.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Yameng SunHong You

Abstract

Progression of liver fibrosis still occurs in some patients with chronic hepatitis B virus (HBV) infection despite antiviral therapy. We aimed to identify risk factors for fibrosis progression in patients who received antiviral therapy. We conducted a longitudinal study of patients with chronic HBV infection and liver biopsies collected before and after 78 weeks of anti-HBV therapy. Fibrosis progression was defined as Ishak stage increase ≥ 1 or as predominantly progressive classified by P-I-R system (Beijing Classification). Levels of HBV DNA and HBV RNA in blood samples were measured by real-time quantitative PCR. HBV RNA in liver tissue was detected by in situ hybridization. A total of 239 patients with chronic HBV infection with paired liver biopsies were included. Among the 163 patients with significant fibrosis at baseline (Ishak ≥ stage 3), fibrosis progressed in 22 patients (13%), was indeterminate in 24 patients (15%), and regressed in 117 patients (72%). Univariate and multivariate analyses revealed that independent risk factors for fibrosis progression were higher rate of detected HBV DNA at week 78 (odds ratio, 4.84; 95% CI, 1.30-17.98; P = .019) and alcohol intake (odds ratio, 23.84; 95% CI, 2.68-212.50; P = .004)....Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Nov 18, 2000·Archives of Pathology & Laboratory Medicine·I R WanlessM Sherman
Oct 8, 2004·The New England Journal of Medicine·Yun-Fan LiawUNKNOWN Cirrhosis Asian Lamivudine Multicentre Study Group
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Mar 13, 2008·Journal of Hepatology·Laurent CasteraAlfredo Alberti
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ting-Tsung ChangBruce Kreter
Dec 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jung Hee KimSeung Woon Paik
Dec 28, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yameng SunJidong Jia
Apr 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Albert D Min
Oct 4, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wai-Kay SetoMan-Fung Yuen
Nov 10, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Shanshan WuJidong Jia
Feb 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultJohn B Wong
Mar 29, 2018·Virchows Archiv : an International Journal of Pathology·Prodromos Hytiroglou, Neil D Theise
Apr 28, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Neil D TheiseHong You
May 13, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jeong Won JangKwang-Hyub Han
May 23, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bingqiong WangHong You
Sep 15, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Norah Terrault
Jul 17, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hannah S J ChoiKeyur Patel

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Citations

Jun 24, 2020·Clinical and Molecular Hepatology·Jung Hee Kim, Dong Hyun Sinn
Dec 15, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Xiaojuan WuLanlan Wang
Jan 7, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Zhong-Bin LiDong Ji
Jul 24, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Lorenza N C DezanetAnders Boyd

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