Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy

The Journal of Infectious Diseases
Edana CassolTheresa Rossouw

Abstract

Microbial translocation contributes to immune activation and disease progression during chronic human immunodeficiency virus type 1 (HIV-1) infection. However, its role in the African AIDS epidemic remains controversial. Here, we investigated the relationship between markers of monocyte activation, plasma lipopolysaccharide (LPS), and HIV-1 RNA in South Africans prioritized to receive combination antiretroviral therapy (cART). Ten HIV-1-negative African controls and 80 HIV-1-infected patients with CD4 T cell counts <200 cells/microL were sampled prior to (n=60) or during (n=20) receipt of effective cART. Viral load was measured by Nuclisens; LPS by the Limulus amoebocyte lysate assay; monocyte and T cell subsets by flow cytometry; and soluble CD14, cytokines, and chemokines by enzyme-linked immunosorbent assay and customized Bio-Plex plates. Three distinct sets of markers were identified. CCL2, CXCL10, and CD14(+)CD16(+) monocyte levels were positively correlated with HIV-1 viremia. This finding, together with cART-induced normalization of these markers, suggests that their upregulation was driven by HIV-1. Plasma interleukin-6 was associated with the presence of opportunistic coinfections. Soluble CD14 and tumor necrosis facto...Continue Reading

Citations

Apr 25, 2012·Current HIV/AIDS Reports·Peter W Hunt
Aug 27, 2013·AIDS Research and Human Retroviruses·Felicity FitzgeraldNigel Klein
Apr 27, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kaku A ArmahMatthew Freiberg
Jan 12, 2011·The Journal of Infectious Diseases·Andrew D ReddThomas C Quinn
Feb 1, 2011·The Journal of Infectious Diseases·Edana CassolSharon Cassol
Mar 13, 2013·The Journal of Infectious Diseases·Zahra ToossiChristina S Hirsch
May 21, 2013·The Journal of Infectious Diseases·Athena P KourtisDenise J Jamieson
Jan 9, 2013·Clinical Microbiology Reviews·Giulia MarchettiGuido Silvestri
Jan 10, 2012·Annual Review of Immunology·Jason M Brenchley, Daniel C Douek
Dec 14, 2011·The Journal of Clinical Investigation·Maud MavignerPierre Delobel
Apr 24, 2012·The Journal of Clinical Investigation·Ravi Dyavar ShettyRama Rao Amara
Dec 18, 2013·AIDS Research and Therapy·Denise C HsuJintanat Ananworanich
Jun 3, 2011·World Journal of Gastroenterology : WJG·Gyongyi Szabo, Samir Zakhari
May 5, 2012·The American Journal of Tropical Medicine and Hygiene·Andrew Prendergast, Paul Kelly
Jan 28, 2014·Journal of the International AIDS Society·Samir AbdurahmanAnders Sönnerborg
Apr 9, 2011·Biomarkers in Medicine·Gregor F LichtfussSharon R Lewin
Jan 15, 2014·Current HIV/AIDS Reports·Anna C HearpsSuzanne M Crowe
Aug 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodolphe ThiébautUNKNOWN French ANRS HIV-2 CO5 Cohort
Feb 19, 2014·The Journal of Antimicrobial Chemotherapy·Consuelo ViladésUNKNOWN HALS Study Group
Jul 16, 2014·Gastroenterology Research and Practice·Felix Chinweije NwosuKnut Rudi
Sep 4, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith SchoutenUNKNOWN AGEhIV Cohort Study Group

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