Persistent neuroendocrine changes in multiple hormonal axes after a single or repeated stressor exposures

Stress : the International Journal on the Biology of Stress
R J ServatiusJ E Ottenweller

Abstract

Many researchers have studied acute responses to stress in animals and how they are modified by prior stressor exposure, but relatively few have examined whether responses to stressors might last for prolonged periods of time. We have previously demonstrated that trough plasma corticosterone levels in rats are elevated for three to five days after single or repeated exposures to mild restraint and inescapable tailshock. The current study measured other aspects of the adrenal axis, and activity in other neuroendocrine systems, 24 hours after one or three consecutive exposures to the same stress paradigm. The data indicated persistent activation of the adrenal axis and prolactin levels, whereas the thyroid and reproductive hormone axes were inhibited after either one or three stress sessions. These changes are remarkable in that one would have expected acute responses to even intense stressors to have ended within hours after the end of the stressor. It will be important to understand the interactions among these responding neuroendocrine systems and to know how long such persistent changes last. Finally, it will be critical to understand the relative contributions of neuroendocrine and psychological factors in maintaining these ...Continue Reading

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Citations

Oct 30, 2003·Brain, Behavior, and Immunity·Staci D Bilbo, Randy J Nelson
Apr 19, 2002·International Immunopharmacology·Dafne Magalí SilbermanAna María Genaro
Jul 14, 2010·Behavioural Brain Research·Thomas M RicartRichard J Servatius
May 16, 2007·Journal of Applied Toxicology : JAT·Mojmir MachJames B Lucot
Jun 22, 2011·Hormones and Behavior·Dana L Helmreich, Daniel Tylee
Sep 10, 2011·Neuropharmacology·Emerson L OlivaresFábio F Rocha
Jan 8, 2015·The Journal of Endocrinology·Patricia Joseph-BravoJean-Louis Charli
Nov 1, 2005·Physiology & Behavior·Dana L HelmreichDavid B Parfitt
Feb 8, 2008·Experimental Animals·Yea Eun LeeYun-Bae Kim
Mar 13, 2014·Endocrinology·Rosa María UribePatricia Joseph-Bravo
Jul 14, 2021·ELife·Inbal Ben-Ami BartalDaniela Kaufer

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