Persistent obesity in rats following a period of consumption of a mixed, high energy diet

The Journal of Physiology
B J RollsR C Turner

Abstract

1. Adult male hooded rats which were offered a mixed, high energy diet for 90 days were hyperphagic and became significantly obese compared to chow-fed control rats. Fasting plasma insulin and glucose levels were initially elevated in the experimental rats, but later in the 90 day period were similar to control levels. 2. When the high energy foods were withdrawn after 90 days and just chow was available, the obese rats maintained the elevated body weights. The obese rats were initially hypophagic, but chow intakes rapidly reached control levels. Plasma insulin and glucose levels were similar in both groups, suggesting that the persisting obesity may not be associated with altered insulin resistance. 3. Five weeks after withdrawal of the 'fattening' diet, half of the experimental rats were offered restricted access to chow for 27 days to reduce their weights to control levels. When the rats were again given free access to chow, they returned to the previously elevated weight. 4. Eighteen weeks after withdrawal of the 'fattening' diet, the experimental rats had significantly elevated body weights and fat stores. The elevated body weight was not simply due to increased growth because, although the experimental rats had slightly m...Continue Reading

Citations

Dec 6, 2003·Eating and Weight Disorders : EWD·B BerraondoJ A Martinez
Jan 15, 2014·Eating Behaviors·Devina Wadhera, Elizabeth D Capaldi-Phillips
Dec 7, 2011·The Journal of Physiological Sciences : JPS·Takashi HiguchiTakuya Murata
Dec 2, 1992·Molecular and Cellular Biochemistry·M EsteveM Alemany
May 1, 1984·Journal of the Autonomic Nervous System·J Louis-Sylvestre
Jul 1, 1994·Physiology & Behavior·M EsteveM Alemany
May 1, 1982·Physiology & Behavior·E HirschH L Jacobs
Mar 1, 1982·Physiology & Behavior·B J Rolls, E A Rowe
Feb 1, 1982·Physiology & Behavior·E A Rowe, B J Rolls
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·P J Rogers, J E Blundell
Mar 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M EsteveM Alemany
Mar 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A M ProenzaA Palou
Aug 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·C PicóA Palou
Jan 24, 1998·Archives of Physiology and Biochemistry·F BaladaM Alemany
Aug 1, 1990·Archives internationales de physiologie et de biochimie·M GianottiA Palou
Jun 1, 1985·Appetite·J M Slattery, R M Potter
Nov 1, 1984·Clinics in Endocrinology and Metabolism·N J Rothwell, M J Stock
Dec 18, 2012·Experimental Physiology·Femke P M HoevenaarsEvert M van Schothorst
Aug 1, 1991·Appetite·H R Kissileff
Dec 29, 2004·Physiology & Behavior·George A BrayBarry M Popkin
Feb 1, 1987·Appetite·J Danguir
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·I Ramirez
Dec 18, 2013·Appetite·Yada Treesukosol, Timothy H Moran
Dec 5, 2009·Critical Reviews in Food Science and Nutrition·Emily J McAllisterDavid B Allison
Jun 1, 1982·The Proceedings of the Nutrition Society·P TrayhurnW P James
Sep 1, 1980·The Proceedings of the Nutrition Society·M I Gurr
Nov 1, 1981·Pflügers Archiv : European journal of physiology·D N StephensC Proffitt

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