Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study

Environmental Health : a Global Access Science Source
Panu RantakokkoJussi Pihlajamäki

Abstract

In animal experiments persistent organic pollutants (POPs) cause hepatosteatosis. In epidemiological studies POPs have positive associations with serum markers of nonalcoholic fatty liver disease (NAFLD) and together with obesity synergistic association with insulin resistance. Because insulin resistance and obesity are critical in NAFLD pathogenesis, we investigated the association of serum pollutant levels with liver histology and alanine aminotransferase (ALT) in morbidly obese. Liver biopsies were from 161 participants of the Kuopio Obesity Surgery Study (KOBS) who underwent bariatric surgery 2005-2011. Liver histology was categorized as normal, steatosis and non-alcoholic steatohepatitis (NASH). Liver phenotype at baseline and ALT at baseline and 12 months post-surgery were correlated to serum POP concentrations at respective time points. As lipophilic POPs concentrate to smaller fat volume during weight loss, serum levels before and 12 months after bariatric surgery were compared. Baseline serum concentration of PCB-118, β-HCH and several PFAAs had an inverse association with lobular inflammation possibly due to changes in bile acid metabolism. ALT had negative associations with many POPs at baseline that turned positive ...Continue Reading

References

May 1, 1979·Chemico-biological Interactions·K K KohliJ D McKinney
Apr 1, 1990·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·S NarayanU K Misra
May 1, 1996·American Journal of Industrial Medicine·F D Gilliland, J S Mandel
Jul 18, 1997·Biochemical and Biophysical Research Communications·J J DilibertoLinda S Birnbaum
Sep 14, 1999·The American Journal of Gastroenterology·E M BruntB R Bacon
Nov 24, 1999·The American Journal of Medicine·G MarchesiniN Melchionda
Mar 2, 2002·The Journal of Toxicological Sciences·K KitamuraS Watanabe
Jun 16, 2004·Environment International·Hannu KivirantaTerttu Vartiainen
May 4, 2005·Drug and Chemical Toxicology·Xing HanGary W Jepson
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
Feb 14, 2007·The Journal of Nutritional Biochemistry·Ronald J Jandacek, Patrick Tso
May 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauJennifer Seed
Jan 11, 2008·Molecular Nutrition & Food Research·Britta FängströmAke Bergman
May 10, 2008·European Journal of Gastroenterology & Hepatology·Márcia M AranhaCecília M P Rodrigues
Aug 5, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Craig D FisherNathan J Cherrington
Dec 17, 2009·The American Journal of Gastroenterology·Chien-Yu LinPau-Chung Chen
Dec 18, 2009·Metabolism: Clinical and Experimental·Jussi PihlajamäkiHelena Gylling
Jan 13, 2010·Environmental Health Perspectives·Jérôme RuzzinLivar Frøyland
Jun 29, 2010·Environment International·Line S HaugHelle K Knutsen
Sep 8, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J S LimD-H Lee
Mar 31, 2011·European Journal of Gastroenterology & Hepatology·Srinivasan DasarathySatish C Kalhan
Mar 8, 2012·Metabolic Syndrome and Related Disorders·Yasar ColakYusuf Yilmaz
Aug 11, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Sofia CarvalhanaHelena Cortez-Pinto
Oct 9, 2012·Toxicology Letters·Mohammad Madani IbrahimJérôme Ruzzin
Nov 13, 2012·International Journal of Cardiology·Angel Brea, José Puzo
Jan 10, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lars P BechmannAli Canbay
Feb 12, 2013·Current Pharmaceutical Design·Salvatore PettaAntonio Craxì
Jul 31, 2013·Environment International·Francisca PérezMarinella Farré
Aug 29, 2013·Environmental Science & Technology·Yifeng ZhangJonathan W Martin
Feb 4, 2014·Endocrine Reviews·Duk-Hee LeeLaura N Vandenberg
Sep 13, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ming KongZhongping Duan

Citations

Sep 28, 2017·Clinical Epigenetics·Sonia García-CalzónCharlotte Ling
Apr 24, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Heather B ClairMatthew C Cave
Aug 16, 2018·Reviews on Environmental Health·Banrida Wahlang
Apr 18, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hongxue ShiRussell Allen Prough
Oct 6, 2017·Current Environmental Health Reports·Andrea L DeierleinSally Park
Jan 5, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Aina JansenMarit Aralt Skaug
Jan 24, 2020·Environmental Health : a Global Access Science Source·S NarduzziD Porta
Dec 13, 2018·EFSA Journal·EFSA Panel on Contaminants in the Food Chain (CONTAM)Tanja Schwerdtle
Oct 1, 2020·EFSA Journal·EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel)Tanja Schwerdtle
Aug 28, 2020·Brain Research·Arnold R Eiser, Tamas Fulop
Apr 16, 2021·Environment International·Shuilin ZhengFei Yang

Methods Mentioned

BETA
gastric bypass
biopsy
biopsies

Related Concepts

Related Feeds

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.