Persistent organic pollutants and pregnancy complications

The Science of the Total Environment
Melissa M SmarrGermaine M Buck Louis

Abstract

We sought to investigate the relationship between maternal preconception exposures to persistent organic pollutants (POPs) and pregnancy complications, gestational diabetes (GDM) and gestational hypertension. Data from 258 (51%) women with human chorionic gonadotropin (hCG) confirmed pregnancies reaching ≥24weeks gestation, from a prospective cohort of 501 couples who discontinued contraception to attempt pregnancy, were analyzed. Preconception concentrations of 9 organochlorine pesticides (OCPs) and 10 polybrominated diphenyl ethers (PBDEs) were quantified in serum. In separate multiple logistic regression models of self-reported physician diagnosed outcomes: GDM (11%) and gestational hypertension (10%), chemicals were natural log-transformed and rescaled by their standard deviation (SD). Models were adjusted for serum lipids, and then adjusted for age, body mass index, race, and smoking. Models were additionally adjusted for the sum of the remaining POPs in each chemical class. Women's serum concentration of PBDE congener 153 (PBDE-153) was positively associated with an increased odds of GDM per SD increase in log-transformed concentration, for unadjusted (OR=1.36, 95%CI: 1.02-1.81), a priori adjusted (OR=1.38, 95% CI: 1.03-1...Continue Reading

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Citations

May 25, 2016·The Science of the Total Environment·Luca RoncatiTeresa Pusiol
Jun 1, 2016·American Journal of Obstetrics and Gynecology·Luca RoncatiTeresa Pusiol
Oct 17, 2016·Environment International·Marina VafeiadiLeda Chatzi
Apr 9, 2016·Environmental Science and Pollution Research International·Su Hyun ParkSun Ha Jee
May 28, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David K ScovilleJulia Yue Cui
Jul 13, 2019·Nature Reviews. Disease Primers·H David McIntyrePeter Damm
Aug 10, 2018·Current Hypertension Reports·Linda G Kahn, Leonardo Trasande
Jun 5, 2020·Environmental Health : a Global Access Science Source·Julia R VarshavskyTracey J Woodruff
Nov 2, 2018·Environmental Research·Giehae ChoiMelissa M Smarr
May 6, 2019·Reproductive Toxicology·Julia VarshavskyTracey J Woodruff
Jan 4, 2021·Endocrine Reviews·Vasantha PadmanabhanMuraly Puttabyatappa

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