Persistent organic pollutants and risk of type 2 diabetes: A prospective investigation among middle-aged women in Nurses' Health Study II

Environment International
Geng ZongQi Sun

Abstract

Exposure to persistent organic pollutants (POPs) may predispose to the development of type 2 diabetes (T2D), but prospective human evidence is scarce. We investigated the association between plasma-POP concentrations in the late 1990s and incident T2D over 11 years of follow-up in the Nurses' Health Study II. Three organochlorine pesticides and 20 polychlorinated biphenyls (PCBs) were measured in banked plasma from 793 case-control pairs of T2D. In a multiviarate-adjusted model, T2D ORs (95%CIs) comparing extreme POP tertiles (high vs. low) were 1.67 (1.24, 2.23; Ptrend < 0.001) for hexachlorobenzene (HCB), 3.62 (2.57, 5.11; Ptrend < 0.001) for β-hexachlorocyclohexane (β-HCH), 1.55 (1.13, 2.13; Ptrend = 0.05) for p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and 1.95 (1.42, 2.69; Ptrend < 0.001) for total dioxin-like PCBs (DL-PCBs) which included 5 mono-ortho congeners, PCB-105, 118, 156, 157, and 167. Adjustment for previous weight change and body mass index (BMI) at blood draw attenuated these associations, but that for DL-PCBs remained (OR[95% CI] = 1.78[1.14, 2.76]; Ptrend = 0.006). Age, breastfeeding history, previous weight change and BMI at blood draw were significant predictors of plasma POP concentrations. In addit...Continue Reading

Citations

Oct 10, 2019·Environmental Health Perspectives·Herbert P SusmannRuthann A Rudel
Nov 14, 2019·International Journal of Environmental Research and Public Health·Wenjing GuoHuixiao Hong
Dec 6, 2019·Frontiers in Public Health·Michael MambiyaWanyang Liu
Aug 23, 2020·International Journal of Environmental Research and Public Health·Zarish NoreenSomiranjan Ghosh
Oct 7, 2020·Diabetes/metabolism Research and Reviews·Sagar B DuganiAdrian Vella
Oct 28, 2019·Environment International·Lindsay M JaacksDorairaj Prabhakaran
Jul 6, 2020·Environment International·Eun Young ParkMin Kyung Lim
Jan 31, 2021·Diabetes & Metabolism·Dianna J MaglianoUNKNOWN D.E.S.I.R. Study Group
Dec 24, 2020·Annals of Global Health·Philip J LandriganPatrick Rampal
May 28, 2019·Environment International·Kathrin WolfWolfgang Rathmann
Jun 1, 2021·BioMed Research International·Chunxia JiangYong Xu
Jun 29, 2021·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Lesya MarushkaHing Man Chan
Jul 15, 2021·International Journal of Epidemiology·Miquel PortaPaolo Vineis

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