Persistent parasitemia after acute babesiosis

The New England Journal of Medicine
P J KrauseD H Persing

Abstract

Babesiosis, a zoonosis caused by the protozoan Babesia microti, is usually not treated when the symptoms are mild, because the parasitemia appears to be transient. However, the microscopical methods used to diagnose this infection are insensitive, and few infected people have been followed longitudinally. We compared the duration of parasitemia in people who had received specific antibabesial therapy with that in silently infected people who had not been treated. Forty-six babesia-infected subjects were identified from 1991 through 1996 in a prospective, community-based study designed to detect episodes of illness and of seroconversion among the residents of southeastern Connecticut and Block Island, Rhode Island. Subjects with acute babesial illness were monitored every 3 months for up to 27 months by means of thin blood smears, Bab. microti polymerase-chain-reaction assays, serologic tests, and questionnaires. Babesial DNA persisted in the blood for a mean of 82 days in 24 infected subjects without specific symptoms who received no specific therapy. Babesial DNA persisted for 16 days in 22 acutely ill subjects who received clindamycin and quinine therapy (P=0.03), of whom 9 had side effects from the treatment. Among the subje...Continue Reading

References

Oct 13, 1977·The New England Journal of Medicine·T K RuebushA J Sulzer
Oct 1, 1992·Journal of Clinical Microbiology·J V FigueroaG M Buening
Dec 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S C MeldrumD L Morse
Aug 1, 1992·Journal of Clinical Microbiology·D H PersingP A Conrad
Jul 14, 1990·Lancet·K R OngY Inada
Jan 1, 1991·Journal of Clinical Microbiology·P J KrauseA Spielman
May 1, 1988·Annals of Internal Medicine·W E Stamm
Jan 1, 1985·Annual Review of Entomology·A SpielmanJ Piesman
Sep 1, 1980·The American Journal of Tropical Medicine and Hygiene·S M TeutschD D Juranek
May 1, 1982·Annals of Internal Medicine·M WittnerG R Healy
Nov 1, 1994·The Journal of Infectious Diseases·S E MalawistaD H Persing
Jul 1, 1994·The Journal of Infectious Diseases·M A GerberR W Ryan
Apr 1, 1994·The Journal of Infectious Diseases·P J KrauseA Spielman
Oct 1, 1993·The American Journal of Tropical Medicine and Hygiene·K C KainH K Webster
Feb 1, 1993·The Journal of Infectious Diseases·F DresslerA C Steere
Jun 5, 1996·JAMA : the Journal of the American Medical Association·P J KrauseD H Persing
May 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E Falagas, M S Klempner
Aug 1, 1996·The American Journal of Tropical Medicine and Hygiene·M WittnerL M Weiss
Aug 1, 1996·Journal of Clinical Microbiology·P J KrauseA Spielman
May 1, 1997·The Journal of Infectious Diseases·B L HerwaldtM L Eberhard
Mar 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·M F Shaio, K D Yang

❮ Previous
Next ❯

Citations

Jun 26, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A HildebrandtE Straube
Feb 27, 2003·Clinical Evidence·Edward Hayes
Dec 13, 2000·International Journal for Parasitology·A M Kjemtrup, P A Conrad
Mar 6, 2004·Lancet·M Kent FrobergJohan S Bakken
Feb 15, 2003·Trends in Parasitology·David R Allred
May 2, 2002·Transfusion Medicine·L PantanowitzM E Cannon
Nov 18, 2000·The New England Journal of Medicine·P J KrauseA Spielman
Jul 11, 2003·The New England Journal of Medicine·Henry M FederPeter J Krause
Jan 25, 2008·The New England Journal of Medicine·Lawrence Mayer, Susanne Merz
Jun 22, 2012·The New England Journal of Medicine·Edouard Vannier, Peter J Krause
Sep 13, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G P WormserB J Luft
Apr 3, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J C HatcherV E Jimenez-Lucho
Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E A BelongiaJ J Kazmierczak
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C ThompsonP J Krause
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allen C SteereVijay K Sikand
Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Raphael B Stricker
Jan 15, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jatin M VyasGregory K Robbins
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Diana FlorescuEmilia Sordillo
Nov 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Diane M GubernotRobert P Wise
Jun 14, 2003·Vector Borne and Zoonotic Diseases·Peter J Krause
Jul 23, 2009·Surgical Infections·Marcus E SemelJonathan D Gates
Jul 19, 2013·Surgical Infections·Joshua C LeinwandLewis J Kaplan
Jul 20, 1999·Current Opinion in Rheumatology·J Evans
May 3, 2001·The Pediatric Infectious Disease Journal·G A Weinberg
May 6, 2004·Journal of Pediatric Hematology/oncology·Angela RechAlgemir Lunardi Brunetto
Oct 18, 2003·Current Opinion in Hematology·Ritchard G Cable, David A Leiby
Jan 30, 2007·The Pediatric Infectious Disease Journal·Mina RajuPeter J Krause
Jul 22, 2009·Antimicrobial Agents and Chemotherapy·O Nicolas SchwintGlen A Scoles
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·Aaron L Baggish, David R Hill
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·R RyanA Levin
Oct 12, 2010·Clinical Microbiology Reviews·J L N BarrattD Stark
Jan 15, 2011·Clinical Microbiology Reviews·David A Leiby
Jul 25, 2000·Clinical Microbiology Reviews·M J HomerD H Persing
Aug 3, 2012·Clinical and Vaccine Immunology : CVI·Jeffrey W PriestMarianna Wilson
Apr 18, 2000·Infection and Immunity·M J LodesD H Persing
Dec 16, 2011·Journal of Clinical Microbiology·Allen E TealSusan Madison-Antenucci
Sep 4, 2009·Interdisciplinary Perspectives on Infectious Diseases·Edouard Vannier, Peter J Krause
Oct 17, 2003·American Journal of Clinical Pathology·Suman SettyPatricia Ferrieri
Jul 16, 2013·PLoS Pathogens·Cheryl A LoboMarilis Rodrigues
Jun 23, 2011·Infection and Drug Resistance·Raphael B Stricker, Lorraine Johnson
Jun 18, 2004·Emerging Infectious Diseases·Barbara L HerwaldtAjit P Limaye
May 1, 2009·Emerging Infectious Diseases·Van Ngo, Rachel Civen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Babesiosis (ASM)

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Related Papers

The New England Journal of Medicine
D H PersingP A Conrad
The New England Journal of Medicine
P J KrauseA Spielman
Annals of Internal Medicine
M WittnerG R Healy
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
M E Falagas, M S Klempner
© 2022 Meta ULC. All rights reserved