Persistent production of interferon-gamma (IFN-gamma) and IL-12 is essential for the generation of protective immunity against Listeria monocytogenes

Clinical and Experimental Immunology
H XiongM Mitsuyama

Abstract

IFN-gamma and IL-12 are believed to be important in the host defence against Listeria infection in mice. However, the relationship between these two cytokines and generation of protective immunity remains poorly understood. In the present study, it was found that at least 4 days of immunizing infection were required for the generation of protective immunity against L. monocytogenes. Protective immunity was generated only by immunizing infection with virulent strain. Even repeated injections of avirulent strain failed to induce protective immunity. When the immunizing infection was terminated with antibiotics, generation of protective immunity and IFN-gamma-producing ability was impaired, while expression of IFN-gamma and IL-12 was also impaired. The mutual relationship between IFN-gamma and IL-12 in L. monocytogenes infection was analysed in vitro. After neutralization of IL-12, IFN-gamma production was completely blocked and IFN-gamma expression was also inhibited. In contrast, there was no change of IL-12 expression after neutralization of IFN-gamma. Taking all facts into consideration, it may be concluded that persistent production of IFN-gamma induced by persistent production of IL-12 during immunizing infection is essentia...Continue Reading

Citations

Mar 18, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A Blanco QuirósR Andión
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R BrewingtonA Shnyra
Mar 25, 2004·Infection and Immunity·David TorresFrançois Erard

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