Persistent pseudobulbar affect secondary to acute disseminated encephalomyelitis

Socioaffective Neuroscience & Psychology
Zhendong LiYing Wang

Abstract

Pseudobulbar affect (PBA) is a common complication of central nervous system diseases such as stroke, multiple sclerosis, and other neurological diseases, but it remains under-recognized and under-treated in the clinic. PBA caused by acute disseminated encephalomyelitis (ADEM) has rarely been reported. Here, we report a 30-year-old Chinese woman who has experienced PBA from ADEM for 7 years. The patient's principal manifestations were extreme emotions or tears when she saw, heard, or spoke about sad news or other sad things; the durations of these unmanageable emotions were often less than 30 sec, and they occurred at frequencies that ranged from one to several times a day. Occasionally, she laughed uncontrollably while people were talking despite a lack of funny or sad stimuli in the conversation or the surrounding environment. Thus, her social functioning was impaired. This case indicates that the long-term PBA can occur secondarily to ADEM, and this possibility should be considered clinically to ensure timely identification and treatment.

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Citations

Jan 4, 2017·CNS Spectrums·William M Sauvé
Oct 28, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Tina MainkaChristos Ganos
Nov 3, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Peter Bede, Eoin Finegan

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Acute Disseminated Encephalomyelitis

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system. Discover the latest research on acute disseminated encephalomyelitis here.

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