PMID: 7519533Aug 1, 1994Paper

Persistent reduction of complement receptor 3 alpha-chain expressing mononuclear blood cells and transient inhibitory serum factors in Whipple's disease

Clinical Immunology and Immunopathology
Thomas MarthG E Feurle

Abstract

Several small studies have indicated an impaired cell mediated immune response as a possible cause for the delayed elimination of the bacteria in Whipple's disease. A specific defect, however, has not been defined. We examined the expression of cell surface molecules and mitogenic responses of peripheral blood mononuclear cells in 27 patients with Whipple's disease at different disease stages by indirect immunofluorescence and by measurement of [3H]thymidine incorporation, respectively. E-rosette formation and cutaneous reaction to seven recall antigens were determined. Matched healthy donors served as controls. We found a significantly reduced number of cells expressing the complement receptor 3 alpha-chain (= CD11b) in all patients. In florid disease, the number of activated cells (in particular CD58 positive cells) was increased and CD4/CD8 ratios were diminished. Proliferation to phytohemagglutinin and to sheep red blood cells was reduced at all stages of the disease. Serum of control persons reversed this decreased responsiveness especially in patients with active disease. Skin reaction was hypoergic in all patients. Determination of CD58 positive cells increased in patients with active disease may be useful to define the ...Continue Reading

Citations

May 6, 2005·International Journal of Colorectal Disease·A KaltT Marth
Mar 15, 2002·Current Allergy and Asthma Reports·T Marth
Jan 28, 2003·Lancet·Thomas Marth, Didier Raoult
Mar 11, 2000·Neuromuscular Disorders : NMD·T R HelliwellK P Walsh
Feb 28, 2008·Current Opinion in Gastroenterology·Thomas Marth, Thomas Schneider
Jul 4, 2001·Clinical Microbiology Reviews·F Dutly, M Altwegg
Feb 10, 2006·Clinical and Vaccine Immunology : CVI·Benoît DesnuesJean-Louis Mege
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