Persistent regulatory T-cell response 2 years after 3 years of grass tablet SLIT: Links to reduced eosinophil counts, sIgE levels, and clinical benefit

Allergy
Rosa VaronaDomingo Barber

Abstract

In the first 2 years of grass tablet sublingual immunotherapy treatment, we have previously demonstrated a progressive development of a regulatory T-cell response, which was preceded by an early decrease in the frequency of both IL-4+ cells and sIgE levels. A progressive increase in sIgG4 levels and FAB blockage were also found. By monitoring immunological kinetics during 3 years of active treatment + 2 years of follow-up, we aimed to identify key immunological parameters that could explain sustained clinical benefit of grass tablet sublingual immunotherapy. Thirty patients completed the 5-year clinical trial protocol. Although individual responses were heterogeneous, reduction in both sIgE and circulating IL-4+ cells compared to the initial 1- to 4-month peak was maintained throughout the 3-year treatment period and for 2 years after discontinuation. Meanwhile, after a 2-year increase in sIgG4, the levels were stabilized during the third year and decreased post-therapy. FAB inhibition remained significantly inhibited throughout the study compared to preimmunotherapy in 83% of patients. A sustained regulatory T-cell response, after IT cessation, occurs in two-thirds of the patients. There was a statistical association between t...Continue Reading

References

Oct 14, 2003·International Archives of Allergy and Immunology·Sabine Flicker, Rudolf Valenta
Aug 30, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Linda Cox
Aug 4, 2009·The Journal of Allergy and Clinical Immunology·Friedrich HorakMartine Le Gall
Feb 2, 2011·The Journal of Allergy and Clinical Immunology·Louisa K JamesStephen R Durham
Jun 9, 2012·The Journal of Allergy and Clinical Immunology·Ravi S SwamyKari C Nadeau
Jun 16, 2012·The Journal of Allergy and Clinical Immunology·Natalija NovakCezmi Akdis
Dec 3, 2013·The Journal of Allergy and Clinical Immunology·Abel Suárez-FueyoRosa Varona
Mar 4, 2014·The Journal of Allergy and Clinical Immunology·Mübeccel Akdis, Cezmi A Akdis
Apr 16, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K AasbjergP A Würtzen
Sep 10, 2014·Current Allergy and Asthma Reports·David C Jay, Kari C Nadeau
Feb 12, 2015·The Journal of Allergy and Clinical Immunology·Alexandra F SantosGideon Lack
Feb 6, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F GomezC Mayorga
Jun 29, 2017·Immunological Reviews·Oscar PalomaresCezmi A Akdis
Jul 12, 2017·The Journal of Allergy and Clinical Immunology·Erkka ValovirtaUNKNOWN GAP investigators
Sep 28, 2017·International Archives of Allergy and Immunology·Katsuyo Ohashi-DoiKaare Lund
Nov 7, 2017·Molecular Nutrition & Food Research·Francisca PalomaresCristobalina Mayorga
Dec 10, 2017·The Journal of Allergy and Clinical Immunology·Mohamed H Shamji, Stephen R Durham
May 1, 2018·The Journal of Allergy and Clinical Immunology·Domenico RosaceDomingo Barber

❮ Previous
Next ❯

Citations

Feb 26, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Johanna HuomanMaria C Jenmalm
Jun 4, 2019·Human Vaccines & Immunotherapeutics·Domingo BarberMaria M Escribese
Jun 18, 2019·Molecular Nutrition & Food Research·Stephanie EichhornGabriele Gadermaier
May 22, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Montserrat Alvaro-LozanoMarta Vazquez-Ortiz
Sep 10, 2020·Allergy·Yifan MengLuo Zhang
Oct 2, 2020·Current Opinion in Allergy and Clinical Immunology·Zeynep Celebi SözenerCezmi Akdis
Dec 2, 2020·Journal of Clinical Medicine·Ibon Eguiluz-GraciaCarmen Rondon
Dec 15, 2020·Current Allergy and Asthma Reports·Gabija DrazdauskaitėMohamed H Shamji
Mar 16, 2021·Frontiers in Immunology·Javier Sanchez-SolaresCristina Gomez-Casado
Sep 10, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Umut C KucuksezerCezmi A Akdis
Apr 11, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tetsuya TeradaTakeshi Nabe
Jun 22, 2021·Frontiers in Immunology·Almudena Testera-MontesIbon Eguiluz-Gracia
Sep 15, 2021·Allergy·Ismail OgulurCezmi A Akdis

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
flow cytometry

Clinical Trials Mentioned

NCT02040844
NCT02943720
NCT02382718
NCT02166268

Software Mentioned

ADC
Kaluza
GraphPad
Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.