PMID: 2498966Jan 1, 1989Paper

Persistent sensitization of clonidine-induced hypokinesia following one exposure to a stressor: possible relevance to panic disorder and its treatment

Psychopharmacology
S M AntelmanD J Edwards

Abstract

Based on previous findings of this laboratory that a single exposure to a stressful stimulus can induce a very long-lasting, sensitizing influence on the actions of drugs of multiple clinical and structural classes, the hypothesis was tested that a single stressful event might exert such an action on the alpha-2 norepinephrine agonist clonidine. Male rats received a single injection of the highly stressful convulsant stimulant pentylenetetrazole (PTZ; 40 mg/kg, IP) and were tested for locomotion after treatment with clonidine (25 micrograms/kg, IP) 1 h, 1 week or 2 weeks later. As expected, clonidine itself induced the hypokinesia typically associated with low doses of this compound. More importantly, all groups pretreated with PTZ showed a significant enhancement of this effect. The influence of PTZ 1 or 2 weeks prior to clonidine cannot be explained as simply due to a lingering impairment of locomotion by PTZ, since no hypokinesia was observed when activity in these groups was examined immediately prior to clonidine administration. Such impairment appears, however, to have been a factor in the heightened hypokinesia observed in the group receiving PTZ only 1 h before clonidine. Mass spectrometric analysis of norepinephrine an...Continue Reading

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Citations

May 1, 1995·Journal of Clinical Psychology·S ThurberK Welter
Aug 3, 2005·Journal of Neural Transmission·K PapanikolaouZ Papadopoulou-Daifoti
Jan 1, 1990·Pharmacology & Therapeutics·D J Nutt
Apr 9, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·S M Antelman, S Gershon
Dec 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·B BirmaherJ Kaufman
Jan 1, 1992·Journal of Child Psychology and Psychiatry, and Allied Disciplines·K D Gadow
Nov 1, 1992·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R Harrington
Jun 3, 2008·Neuroscience and Biobehavioral Reviews·Antonio ArmarioRoser Nadal
Dec 25, 2007·Pharmacology, Biochemistry, and Behavior·Robert J CareyJoseph P Huston
Mar 14, 2007·Neuroscience and Biobehavioral Reviews·Rianne Stam

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