Persistent Smell Loss Following Undetectable SARS-CoV-2.

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Carol H YanAdam S DeConde

Abstract

The association of smell and taste loss with COVID-19 has been well demonstrated with high prevalence rates. In certain cases, chemosensory loss may be the only symptom of COVID-19 and may linger while other symptoms have resolved. The significance of persistent smell and taste loss and its relationship to ongoing viral shedding has yet to be investigated. In this cross-sectional study, of the 316 laboratory test-confirmed COVID-19 cases at our institution, 46 had subsequent test-based confirmation of viral clearance with 2 consecutive negative RT-PCR test results (reverse transcriptase polymerase chain reaction). Olfactory dysfunction was reported by 50% of the patients (23 of 46), with 78% (18 of 23) having subjective persistent smell loss despite negative RT-PCR test results. These preliminary data demonstrate the persistence of self-reported smell loss despite otherwise clinical resolution and undetectable nasal viral RNA.

References

Mar 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea GiacomelliMassimo Galli
Apr 8, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez
Apr 13, 2020·International Forum of Allergy & Rhinology·Carol H YanAdam S DeConde
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Giacomo SpinatoPaolo Boscolo-Rizzo
Apr 29, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rachel KayeJames C Denneny
May 6, 2020·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Claire HopkinsB Nirmal Kumar
May 13, 2020·Nature Medicine·Cristina MenniTim D Spector
May 13, 2020·International Forum of Allergy & Rhinology·Claire HopkinsGiacomo De Riu

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Citations

Jan 27, 2021·Journal of Korean Medical Science·Jeong Whun KimJin Youp Kim
Feb 10, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Alberto PadernoCesare Piazza
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Nov 13, 2021·Cardiovascular Endocrinology & Metabolism·UNKNOWN Research Accessibility Team (RAT)

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