Persistent suppression of resting energy expenditure after acute hypoxia

Metabolism: Clinical and Experimental
Kerstin M OltmannsAchim Peters

Abstract

Resting energy expenditure (REE) is known to be influenced by various ambient conditions such as oxygen supply. Investigations in healthy subjects during acute hypoxia revealed a drop in REE, but persistent effects after hypoxia had ended have not been examined so far. Although indirect calorimetry is a well-established method to measure REE, it may lead to false conclusions when hyperventilation, rise in lactate or catecholamines, and decrease of food intake accompany hypoxia. Therefore, we determined REE in healthy men after hypoxia had ended and under conditions of controlled energy supply during a glucose clamp. In a double-blind crossover study design, we induced hypoxia for 30 minutes by decreasing oxygen saturation to 75% (vs 96% in a control session) in 13 healthy men. Indirect calorimetry was performed at baseline and 150 minutes after hypoxia had ended. Plasma glucose was held stable between 4.5 and 5.5 mmol/L, and lactate as well as catecholamine concentrations were monitored. In parallel, we measured alterations in hormones of the hypothalamic-pituitary-thyroid axis, which is one known factor mediating changes in REE. Resting energy expenditure was decreased after hypoxia (from 1656+/-80 to 1564+/-97 kcal/d) as comp...Continue Reading

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Citations

Jul 1, 2010·Fiziologiia cheloveka·E R BoĭkoS I Soroko
Dec 1, 2009·International Journal of Endocrinology·Andre SchmollerKerstin M Oltmanns
Aug 6, 2014·European Journal of Applied Physiology·Tadej DebevecIgor B Mekjavic
Mar 13, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Loes P M DuivenvoordeJaap Keijer
May 15, 2015·Sleep & Breathing = Schlaf & Atmung·Katalin FeketeIoannis Kioumis
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Sebastian M SchmidBernd Schultes
Nov 1, 2007·Expert Review of Endocrinology & Metabolism·Sebastian M SchmidBernd Schultes
Jan 21, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Bengt Kayser, Samuel Verges

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