Persistent symptomatic improvement in the majority of patients undergoing parathyroidectomy for primary hyperparathyroidism.

Langenbeck's Archives of Surgery
Preethi GopinathRadu Mihai

Abstract

Parathyroidectomy for primary hyperparathyroidism (PHPT) is followed by a decrease in the severity of symptoms reported on the Pasieka's parathyroid symptoms score (PPSS) and SF-36 questionnaires. Some argue that such benefits are short-lived. This study investigates the severity of symptoms at more than 12 months after parathyroidectomy. A prospective database collected clinical/operative data on consecutive patients with PHPT. PPSS was calculated as the sum of the 13 parameters self-assessed using a visual analog scale. SF-36(v2) was analyzed using commercially available software (QualityMetric Inc., Lincoln, USA). Over 3-year interval, 166 patients (119 F/47 M, age 15-89 years) were operated for with PHPT (Ca 2.90 ± 0.25 mmol/L, PTH 21.64 ± 23.05 pmol/L). Their preoperative PPSS ranged 0-1,260 (median 413) and did not correlate with the severity of hypercalcemia. One hundred and seven patients responded when contacted by post at 18 ± 6 months postoperatively. Their postoperative PPSS was significantly lower (398 ± 226 to 231 ± 203, p < 0.001) and in 55 of 107 patients the severity of symptoms reduced by at least 50%. Most significant improvements were for mood (36 ± 33 vs. 16 ± 23), weakness/tiredness (37 ± 32 vs. 17 ± 23), ...Continue Reading

References

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Citations

Aug 17, 2010·Langenbeck's Archives of Surgery·Bruno Niederle
Dec 14, 2011·Langenbeck's Archives of Surgery·Dominika BabińskaZbigniew Sledziński
Aug 27, 2013·Langenbeck's Archives of Surgery·Irene Hamrick, Frank Meyer
Apr 2, 2014·The Journal of Surgical Research·Priya R PathakRebecca S Sippel
Mar 6, 2019·Journal of Clinical Medicine·Young Jun ChaiSang Wan Kim
Mar 1, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Georgios TzikosTheodosios Papavramidisos

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