Persistent T-wave inversion predicts myocardial damage after ST-elevation myocardial infarction

International Journal of Cardiology
Martin ReindlBernhard Metzler

Abstract

Persistent T-wave inversion (PTI) after ST-elevation myocardial infarction (STEMI) is associated with worse clinical outcome; however, the underlying mechanism between PTI and poor prognosis is incompletely understood. We sought to investigate the relationship between PTI and myocardial damage assessed by cardiac magnetic resonance (CMR) following STEMI. In this prospective observational study, we included 142 consecutive revascularized STEMI patients. Electrocardiography to determine the presence and amplitude of PTI and pathological Q-waves was conducted 4months after infarction. CMR was performed within 1week after infarction and at 4months follow-up to evaluate infarct characteristics and myocardial function. Patients with PTI (n=103, 73%) showed a larger acute (21[11-29] vs. 6[1-13]%; p<0.001) and chronic infarct size (IS) (14[8-19] vs. 3[1-8]%; p<0.001) and more frequently microvascular obstruction (59 vs. 33%; p=0.02). The association between PTI and chronic IS remained significant (odds ratio: 9.02, 95%CI 3.49-23.35; p<0.001) after adjustment for pathological Q-wave and other IS estimators (high-sensitivity cardiac troponin T and C-reactive protein, N-terminal pro B-type natriuretic peptide, culprit vessel, pre-interven...Continue Reading

References

Oct 11, 2015·European Heart Journal. Acute Cardiovascular Care·Hans-Josef FeistritzerBernhard Metzler

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Citations

Feb 1, 2020·Journal of the American Heart Association·Martin ReindlSebastian J Reinstadler
Sep 26, 2020·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Tiia IstolahtiJussi Hernesniemi
Feb 7, 2021·Open Heart·Christina TillerSebastian Johannes Reinstadler

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