PMID: 7855176Jan 1, 1993

Persistent vacuous chewing in rats following neuroleptic treatment: relationship to dopaminergic and cholinergic function

B Glenthøj


In order to relate the effects of pharmacological intervention to neuroleptic induced increases in oral activity rats were treated continuously (7 mg/kg per week) or discontinuously (7 mg/kg per week or 2 mg/kg per week) with haloperidol for 6 months. Only the two intermittently treated groups developed persisting increases in vacuous chewing movements (VCM) following drug withdrawal. Opposed to control animals and continuously treated rats, the discontinuously treated groups demonstrated significant elevation in mouth movements following stimulation with the dopamine (DA) D1 receptor agonist SK&F 38393 (23 mg/kg), whereas they did not response to an acute challenge with the selective DA D1 receptor antagonist NNC-756 (0.1 mg/kg). The DA D2 receptor antagonist raclopride (1 mg/kg) provoked a general fall in VCM; however, this was only significant in rats treated intermittently with haloperidol 7 mg/kg per week and in control rats. Intermittent neuroleptic treatment also increased apomorphine-induced stereotypy. The effect of challenge with the anticholinergic drug scopolamine (0.25 mg/kg) was not related to oral activity; furthermore, the finding of severe agitation in rats tested with the latter drug points to caution in the i...Continue Reading


Feb 18, 1992·European Journal of Pharmacology·M DianaG L Gessa
Jan 1, 1991·Life Sciences·B Glenthøj, R Hemmingsen
Nov 13, 1990·European Journal of Pharmacology·B GlenthøjT G Bolwig
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Dec 4, 1998·Biological Psychiatry·H Rosengarten, A J Friedhoff
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