PMID: 7855176Jan 1, 1993

Persistent vacuous chewing in rats following neuroleptic treatment: relationship to dopaminergic and cholinergic function

Psychopharmacology
B Glenthøj

Abstract

In order to relate the effects of pharmacological intervention to neuroleptic induced increases in oral activity rats were treated continuously (7 mg/kg per week) or discontinuously (7 mg/kg per week or 2 mg/kg per week) with haloperidol for 6 months. Only the two intermittently treated groups developed persisting increases in vacuous chewing movements (VCM) following drug withdrawal. Opposed to control animals and continuously treated rats, the discontinuously treated groups demonstrated significant elevation in mouth movements following stimulation with the dopamine (DA) D1 receptor agonist SK&F 38393 (23 mg/kg), whereas they did not response to an acute challenge with the selective DA D1 receptor antagonist NNC-756 (0.1 mg/kg). The DA D2 receptor antagonist raclopride (1 mg/kg) provoked a general fall in VCM; however, this was only significant in rats treated intermittently with haloperidol 7 mg/kg per week and in control rats. Intermittent neuroleptic treatment also increased apomorphine-induced stereotypy. The effect of challenge with the anticholinergic drug scopolamine (0.25 mg/kg) was not related to oral activity; furthermore, the finding of severe agitation in rats tested with the latter drug points to caution in the i...Continue Reading

References

Feb 18, 1992·European Journal of Pharmacology·M DianaG L Gessa
Jan 1, 1991·Life Sciences·B Glenthøj, R Hemmingsen
Nov 13, 1990·European Journal of Pharmacology·B GlenthøjT G Bolwig
May 19, 1989·European Journal of Pharmacology·B Glenthøj, R Hemmingsen
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·E LevinE Young
Dec 1, 1989·Journal of Clinical Psychopharmacology·W C WirshingG Bartzokis
Sep 1, 1989·Pharmacology, Biochemistry, and Behavior·E LevinD South
Jan 1, 1986·Psychopharmacology·N M RupniakC D Marsden
Oct 1, 1986·Pharmacology, Biochemistry, and Behavior·L M GunneP Johansson
Apr 1, 1988·Acta Psychiatrica Scandinavica·J Gerlach, D E Casey
Dec 1, 1988·The Australian and New Zealand Journal of Psychiatry·P Sachdev
Apr 13, 1988·European Journal of Pharmacology·M RubinsteinF J Stefano
Jan 1, 1988·Annals of the New York Academy of Sciences·P W KalivasR Abhold
Jan 28, 1987·European Journal of Pharmacology·P JohanssonG Ellison
Jan 1, 1984·Psychopharmacology·R J Carey, J DeVeaugh-Geiss
Sep 1, 1984·Biological Psychology·J G O'Gorman
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Jun 4, 1993·European Journal of Pharmacology·B GlenthøjT G Bolwig

Citations

Dec 4, 1998·Biological Psychiatry·H Rosengarten, A J Friedhoff
Nov 5, 1997·Pharmacology, Biochemistry, and Behavior·S PeciñaL A Parker
Jan 13, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·H RosengartenA J Friedhoff
Aug 9, 2011·Neuropsychiatric Disease and Treatment·Takahiko Nagamine
Feb 12, 2005·Biological Psychiatry·Peter TurroneJosé N Nobrega
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter TurroneJosé N Nobrega
Jun 20, 2019·Current Protocols in Neuroscience·Fausto Pierdoná GuzenDayane Pessoa de Araújo

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