Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregivers.

Journal of Affective Disorders
Kirstin AschbacherIgor Grant

Abstract

Depressive symptoms and caregiving stress may contribute to cardiovascular disease (CVD) via chronic platelet activation; however, it remains unclear whether this elevated activation constitutes a trait or state marker. The primary objective was to investigate whether persistent depressive symptoms would relate to elevated platelet activation in response to acute psychological stress over a three-year period. Depressive symptoms (Brief Symptom Inventory) were assessed among 99 spousal dementia caregivers (52-88 years). Platelet P-selectin expression was assessed in vivo using flow cytometry at three time-points over the course of an acute stress test: baseline, post-stress, and after 14 min of recovery. Two competing structural analytic models of depressive symptoms and platelet hyperactivity with three yearly assessments were compared. Although depressive symptoms were generally in the subclinical range, their persistent elevation was associated with heightened platelet reactivity and recovery at all three-years while the change in depressive symptoms from the previous year did not predict platelet activity. These results focus on caregivers providing consistent home care, while future studies may extend these results by model...Continue Reading

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Citations

Apr 12, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Ea Wha KangMark Unruh
Dec 24, 2009·Cardiovascular Psychiatry and Neurology·Hu Chen
Sep 25, 2010·Psychoneuroendocrinology·Anđelko VidovićAnte Sabioncello
Jul 21, 2015·Physiology & Behavior·Katharina HüfnerBarbara Sperner-Unterweger
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Aug 7, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Pia Koudouovoh-TrippBarbara Sperner-Unterweger

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