Persistently high serum carcinoembryonic antigen levels after surgery indicate poor prognosis in patients with stage I non-small-cell lung cancer

The Journal of Surgical Research
Chien-Ying WangHan-Shui Hsu

Abstract

The aim of this study is to evaluate the prognostic significance of preoperative and postoperative serum carcinoembryonic antigen (CEA) levels in patients with stage I non-small-cell lung cancer. A retrospective review of the medical records of 257 patients with stage I lung cancer undergoing surgical resection was performed. The clinical data of each patient was collected for analysis including age, smoking habits, gender, preoperative and postoperative serum CEA levels, tumor diameter, histologic type, visceral pleural invasion, pathologic stage, and type of operation. Adenocarcinoma was more often associated with elevated preoperative CEA level compared with non-adenocarcinoma. Tumor histology, however, did not influence postoperative CEA levels. In the univariate analysis, age, serum CEA level, and pathologic stage were prognostic factors. Patients with normal preoperative serum CEA levels had better 5-y survival than patients with high preoperative serum CEA levels (71.1% versus 54.6%, P = 0.016). The patients with a persistently high serum CEA level after surgery had worst prognosis. Multivariate analysis demonstrated that older age (≥65) and persistently high serum CEA levels were independent significant prognostic facto...Continue Reading

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Citations

Aug 28, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Naoki OzekiKohei Yokoi
Jan 25, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ryo MaedaKanji Nagai
Apr 14, 2016·Journal of Cancer Research and Therapeutics·Qin HuPijun Yu
Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Masaki TomitaKunihide Nakamura
Mar 30, 2020·Interactive Cardiovascular and Thoracic Surgery·Khashchuluun BatmunkhSanghoon Jheon

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