PMID: 9545113Apr 17, 1998Paper

Persistently increased gastrin and decreased pepsinogen concentrations in serum from some patients with Graves' disease of triiodothyronine-predominant type and common type

Thyroid : Official Journal of the American Thyroid Association
A FukaoN Ohsawa

Abstract

This study aimed to investigate the cause of persistently increased serum gastrin concentration seen in some Graves' disease patients even when euthyroid during antithyroid drug treatment. The subjects studied consisted of three groups: 33 patients with a common-type of Graves' disease, 14 with triiodothyronine (T3)-predominant Graves' disease (characterized from previous studies as having potent immunologic abnormalities including greater concentrations of thyroid-stimulating antibodies together with larger goiter size), and a group of 20 normal subjects. Fasting serum gastrin concentrations in common Graves' disease patients were significantly higher than those of normal subjects (58.4 +/- 38.9 pmol/L vs. 37.8 +/- 18.9 pmol/L [mean +/- SD], p < 0.05). The serum gastrin concentrations were even greater in T3-predominant Graves' disease patients than common Graves' disease patients (162.9 +/- 224.0 pmol/L vs. 58.4 +/- 38.9 pmol/L, p < .05). Serum pepsinogen I (PGI) concentrations were significantly lower in the T3-predominant patient group than the common Graves' group (24.0 +/- 12.9 ng/mL vs. 39.7 +/- 19.6 ng/mL, p < .05). Serum ratios of PG I to PG II were significantly lower in the T3-predominant Graves' disease patients tha...Continue Reading

References

Mar 11, 1978·Lancet·W S RuddellC L Walters
Oct 1, 1976·The Journal of Clinical Endocrinology and Metabolism·Y SeinoH Imura
Sep 1, 1975·Australasian Radiology·N R JeffersonS Rajapakse
Jan 1, 1988·Digestion·W Creutzfeldt
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J TakamatsuT Mozai
Apr 1, 1987·Gastroenterologia Japonica·K MikiK Takahashi
Oct 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M K MüllerH Goebell
Feb 1, 1980·The Journal of Clinical Endocrinology and Metabolism·Y SeinoH Imura
Feb 1, 1981·Clinical Endocrinology·P A DahlbergG Lundqvist
Nov 1, 1980·Acta Endocrinologica·W M Wiersinga, J L Touber
Dec 26, 1964·British Medical Journal·J R ANDERSONJ A YOUNG

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